1d5b
From Proteopedia
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==UNLIGANDED MATURE OXY-COPE CATALYTIC ANTIBODY== | ==UNLIGANDED MATURE OXY-COPE CATALYTIC ANTIBODY== | ||
<StructureSection load='1d5b' size='340' side='right' caption='[[1d5b]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='1d5b' size='340' side='right' caption='[[1d5b]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1d5b]] is a 4 chain structure | + | <table><tr><td colspan='2'>[[1d5b]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D5B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D5B FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1axs|1axs]], [[1d5i|1d5i]], [[1d6v|1d6v]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1axs|1axs]], [[1d5i|1d5i]], [[1d6v|1d6v]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d5b OCA], [http://pdbe.org/1d5b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1d5b RCSB], [http://www.ebi.ac.uk/pdbsum/1d5b PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d5b OCA], [http://pdbe.org/1d5b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1d5b RCSB], [http://www.ebi.ac.uk/pdbsum/1d5b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1d5b ProSAT]</span></td></tr> |
</table> | </table> | ||
| - | == Disease == | ||
| - | [[http://www.uniprot.org/uniprot/IGKC_HUMAN IGKC_HUMAN]] Defects in IGKC are the cause of immunoglobulin kappa light chain deficiency (IGKCD) [MIM:[http://omim.org/entry/614102 614102]]. IGKCD is a disease characterized by the complete absence of immunoglobulin kappa chains.<ref>PMID:3931219</ref> [[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[ | + | *[[3D structures of monoclonal antibody|3D structures of monoclonal antibody]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Lk3 transgenic mice]] | ||
[[Category: Hanson, M A]] | [[Category: Hanson, M A]] | ||
[[Category: Mundorff, E C]] | [[Category: Mundorff, E C]] | ||
Revision as of 10:35, 3 August 2017
UNLIGANDED MATURE OXY-COPE CATALYTIC ANTIBODY
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