Endonuclease
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='1rva' size='350' side='right' scene='' caption='E. coli EcoRV endonuclease dimer ( | + | <StructureSection load='1rva' size='350' side='right' scene='49/496318/Cv/1' caption='E. coli EcoRV endonuclease dimer (magenta, green) complex with DNA, (PDB code [[1rva]])'> |
== Function == | == Function == | ||
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== Disease == | == Disease == | ||
| - | Mutation in UV-specific ENN causes Xeroderma pigmentosa. Mutations in tRNA-splicing ENN cause pontocerebellar hypoplasia. | + | Mutation in UV-specific ENN causes Xeroderma pigmentosa. Mutations in tRNA-splicing ENN cause pontocerebellar hypoplasia. |
| + | |||
| + | == Structural highlights == | ||
| + | <scene name='49/496318/Cv/1'>E. coli EcoRV endonuclease dimer with DNA</scene> (PDB code [[1rva]]). | ||
</StructureSection> | </StructureSection> | ||
==3D structures of endonuclease== | ==3D structures of endonuclease== | ||
Revision as of 12:46, 9 February 2016
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3D structures of endonuclease
Updated on 09-February-2016
References
- ↑ Nishino T, Morikawa K. Structure and function of nucleases in DNA repair: shape, grip and blade of the DNA scissors. Oncogene. 2002 Dec 16;21(58):9022-32. PMID:12483517 doi:http://dx.doi.org/10.1038/sj.onc.1206135
- ↑ Horvath P, Barrangou R. CRISPR/Cas, the immune system of bacteria and archaea. Science. 2010 Jan 8;327(5962):167-70. doi: 10.1126/science.1179555. PMID:20056882 doi:http://dx.doi.org/10.1126/science.1179555
- ↑ Flick KE, Jurica MS, Monnat RJ Jr, Stoddard BL. DNA binding and cleavage by the nuclear intron-encoded homing endonuclease I-PpoI. Nature. 1998 Jul 2;394(6688):96-101. PMID:9665136 doi:10.1038/27952
