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2chx

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==A PHARMACOLOGICAL MAP OF THE PI3-K FAMILY DEFINES A ROLE FOR P110ALPHA IN SIGNALING: THE STRUCTURE OF COMPLEX OF PHOSPHOINOSITIDE 3-KINASE GAMMA WITH INHIBITOR PIK-90==
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==A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-90==
<StructureSection load='2chx' size='340' side='right' caption='[[2chx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='2chx' size='340' side='right' caption='[[2chx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=090:N-(2,3-DIHYDRO-7,8-DIMETHOXYIMIDAZO[1,2-C]+QUINAZOLIN-5-YL)NICOTINAMIDE'>090</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=090:N-(2,3-DIHYDRO-7,8-DIMETHOXYIMIDAZO[1,2-C]+QUINAZOLIN-5-YL)NICOTINAMIDE'>090</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e8y|1e8y]], [[1e8z|1e8z]], [[1he8|1he8]], [[2a4z|2a4z]], [[2a5u|2a5u]], [[2chw|2chw]], [[2chz|2chz]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e8y|1e8y]], [[1e8z|1e8z]], [[1he8|1he8]], [[2a4z|2a4z]], [[2a5u|2a5u]], [[2chw|2chw]], [[2chz|2chz]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2chx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chx OCA], [http://pdbe.org/2chx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2chx RCSB], [http://www.ebi.ac.uk/pdbsum/2chx PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2chx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chx OCA], [http://pdbe.org/2chx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2chx RCSB], [http://www.ebi.ac.uk/pdbsum/2chx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2chx ProSAT]</span></td></tr>
</table>
</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
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Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/2chx_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/2chx_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>

Revision as of 08:05, 23 May 2018

A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-90

2chx, resolution 2.50Å

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