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2c7u

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Revision as of 08:04, 23 May 2018

Conflicting selective forces affect CD8 T-cell receptor contact sites in an HLA-A2 immunodominant HIV epitope.

Structural highlights

2c7u is a 6 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1a1m, 1a1n, 1a1o, 1a6z, 1a9b, 1a9e, 1agb, 1agc, 1agd, 1age, 1agf, 1akj, 1ao7, 1aqd, 1b0g, 1b0r, 1bd2, 1c16, 1ce6, 1cg9, 1de4, 1duy, 1duz, 1e27, 1e28, 1eey, 1eez, 1efx, 1exu, 1gzp, 1gzq, 1hhg, 1hhh, 1hhi, 1hhj, 1hhk, 1hla, 1hsa, 1hsb, 1i1f, 1i1y, 1i4f, 1i7r, 1i7t, 1i7u, 1im3, 1im9, 1jf1, 1jht, 1jnj, 1k5n, 1kpr, 1ktl, 1lds, 1lp9, 1m05, 1m6o, 1mhe, 1mi5, 1n2r, 1of2, 1oga, 1ogt, 1onq, 1p7q, 1py4, 1q94, 1qew, 1qr1, 1qrn, 1qse, 1qsf, 1qvo, 1r3h, 1s9w, 1s9x, 1s9y, 1sys, 1syv, 1t1w, 1t1x, 1t1y, 1t1z, 1t20, 1t21, 1t22, 1tmc, 1tvb, 1tvh, 1uqs, 1ur7, 1uxs, 1uxw, 1vgk, 1w0v, 1w0w, 1w72, 1x7q, 1xh3, 1xr8, 1xr9, 1xz0, 1ydp, 1ypz, 1zs8, 1zsd, 1zt4, 2ak4, 2av1, 2av7, 2bnq, 2bnr, 2bsr, 2bss, 2bst, 2bsu, 2bsv, 2bvq, 2clr, 3hla
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[1A02_HUMAN] Involved in the presentation of foreign antigens to the immune system.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Cytotoxic T lymphocytes (CTLs) are critical for the control of human immunodeficiency virus, but containment of virus replication can be undermined by mutations in CTL epitopes that lead to virus escape. We analyzed the evolution in vivo of an immunodominant, HLA-A2-restricted CTL epitope and found two principal, diametrically opposed evolutionary pathways that exclusively affect T cell-receptor contact residues. One pathway was characterized by acquisition of CTL escape mutations and the other by selection for wild-type amino acids. The pattern of CTL responses to epitope variants shaped which variant(s) prevailed in the virus population. The pathways notably influenced the amount of plasma virus, as patients with efficient CTL selection had lower plasma viral loads than did patients without efficient selection. Thus, viral escape from CTL responses does not necessarily correlate with disease progression.

Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope.,Iversen AK, Stewart-Jones G, Learn GH, Christie N, Sylvester-Hviid C, Armitage AE, Kaul R, Beattie T, Lee JK, Li Y, Chotiyarnwong P, Dong T, Xu X, Luscher MA, MacDonald K, Ullum H, Klarlund-Pedersen B, Skinhoj P, Fugger L, Buus S, Mullins JI, Jones EY, van der Merwe PA, McMichael AJ Nat Immunol. 2006 Feb;7(2):179-89. Epub 2006 Jan 1. PMID:16388312^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Iversen AK, Stewart-Jones G, Learn GH, Christie N, Sylvester-Hviid C, Armitage AE, Kaul R, Beattie T, Lee JK, Li Y, Chotiyarnwong P, Dong T, Xu X, Luscher MA, MacDonald K, Ullum H, Klarlund-Pedersen B, Skinhoj P, Fugger L, Buus S, Mullins JI, Jones EY, van der Merwe PA, McMichael AJ. Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope. Nat Immunol. 2006 Feb;7(2):179-89. Epub 2006 Jan 1. PMID:16388312 doi:10.1038/ni1298

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2c7u"

@@ Line 1: / Line 1: @@
-==CONFLICTING SELECTIVE FORCES AFFECT CD8 T-CELL RECEPTOR CONTACT SITES IN AN HLA-A2 IMMUNODOMINANT HIV EPITOPE.==
+==Conflicting selective forces affect CD8 T-cell receptor contact sites in an HLA-A2 immunodominant HIV epitope.==
 <StructureSection load='2c7u' size='340' side='right' caption='[[2c7u]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[2c7u]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C7U FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a1m|1a1m]], [[1a1n|1a1n]], [[1a1o|1a1o]], [[1a6z|1a6z]], [[1a9b|1a9b]], [[1a9e|1a9e]], [[1agb|1agb]], [[1agc|1agc]], [[1agd|1agd]], [[1age|1age]], [[1agf|1agf]], [[1akj|1akj]], [[1ao7|1ao7]], [[1aqd|1aqd]], [[1b0g|1b0g]], [[1b0r|1b0r]], [[1bd2|1bd2]], [[1c16|1c16]], [[1ce6|1ce6]], [[1cg9|1cg9]], [[1de4|1de4]], [[1duy|1duy]], [[1duz|1duz]], [[1e27|1e27]], [[1e28|1e28]], [[1eey|1eey]], [[1eez|1eez]], [[1efx|1efx]], [[1exu|1exu]], [[1gzp|1gzp]], [[1gzq|1gzq]], [[1hhg|1hhg]], [[1hhh|1hhh]], [[1hhi|1hhi]], [[1hhj|1hhj]], [[1hhk|1hhk]], [[1hla|1hla]], [[1hsa|1hsa]], [[1hsb|1hsb]], [[1i1f|1i1f]], [[1i1y|1i1y]], [[1i4f|1i4f]], [[1i7r|1i7r]], [[1i7t|1i7t]], [[1i7u|1i7u]], [[1im3|1im3]], [[1im9|1im9]], [[1jf1|1jf1]], [[1jht|1jht]], [[1jnj|1jnj]], [[1k5n|1k5n]], [[1kpr|1kpr]], [[1ktl|1ktl]], [[1lds|1lds]], [[1lp9|1lp9]], [[1m05|1m05]], [[1m6o|1m6o]], [[1mhe|1mhe]], [[1mi5|1mi5]], [[1n2r|1n2r]], [[1of2|1of2]], [[1oga|1oga]], [[1ogt|1ogt]], [[1onq|1onq]], [[1p7q|1p7q]], [[1py4|1py4]], [[1q94|1q94]], [[1qew|1qew]], [[1qr1|1qr1]], [[1qrn|1qrn]], [[1qse|1qse]], [[1qsf|1qsf]], [[1qvo|1qvo]], [[1r3h|1r3h]], [[1s9w|1s9w]], [[1s9x|1s9x]], [[1s9y|1s9y]], [[1sys|1sys]], [[1syv|1syv]], [[1t1w|1t1w]], [[1t1x|1t1x]], [[1t1y|1t1y]], [[1t1z|1t1z]], [[1t20|1t20]], [[1t21|1t21]], [[1t22|1t22]], [[1tmc|1tmc]], [[1tvb|1tvb]], [[1tvh|1tvh]], [[1uqs|1uqs]], [[1ur7|1ur7]], [[1uxs|1uxs]], [[1uxw|1uxw]], [[1vgk|1vgk]], [[1w0v|1w0v]], [[1w0w|1w0w]], [[1w72|1w72]], [[1x7q|1x7q]], [[1xh3|1xh3]], [[1xr8|1xr8]], [[1xr9|1xr9]], [[1xz0|1xz0]], [[1ydp|1ydp]], [[1ypz|1ypz]], [[1zs8|1zs8]], [[1zsd|1zsd]], [[1zt4|1zt4]], [[2ak4|2ak4]], [[2av1|2av1]], [[2av7|2av7]], [[2bnq|2bnq]], [[2bnr|2bnr]], [[2bsr|2bsr]], [[2bss|2bss]], [[2bst|2bst]], [[2bsu|2bsu]], [[2bsv|2bsv]], [[2bvq|2bvq]], [[2clr|2clr]], [[3hla|3hla]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7u OCA], [http://pdbe.org/2c7u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c7u RCSB], [http://www.ebi.ac.uk/pdbsum/2c7u PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7u OCA], [http://pdbe.org/2c7u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c7u RCSB], [http://www.ebi.ac.uk/pdbsum/2c7u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c7u ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 12: / Line 13: @@
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/2c7u_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/2c7u_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 51: / Line 52: @@
 [[Category: Li, Y]]
 [[Category: Luscher, M A]]
-[[Category: Macdonald, K]]
+[[Category: MacDonald, K]]
-[[Category: Mcmichael, A J]]
+[[Category: McMichael, A J]]
-[[Category: Merwe, P A.Van Der]]
+[[Category: Merwe, P A.van der]]
 [[Category: Mullins, J I]]
 [[Category: Skinhoj, P]]

2c7u

From Proteopedia

Revision as of 08:04, 23 May 2018

Conflicting selective forces affect CD8 T-cell receptor contact sites in an HLA-A2 immunodominant HIV epitope.

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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