1f0v

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[[Image:1f0v.gif|left|200px]]
[[Image:1f0v.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1f0v |SIZE=350|CAPTION= <scene name='initialview01'>1f0v</scene>, resolution 1.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1f0v", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1f0v| PDB=1f0v | SCENE= }}
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|RELATEDENTRY=[[1a2w|1a2w]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0v OCA], [http://www.ebi.ac.uk/pdbsum/1f0v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1f0v RCSB]</span>
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}}
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'''Crystal structure of an Rnase A dimer displaying a new type of 3D domain swapping'''
'''Crystal structure of an Rnase A dimer displaying a new type of 3D domain swapping'''
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[[Category: Libonati, M.]]
[[Category: Libonati, M.]]
[[Category: Liu, Y S.]]
[[Category: Liu, Y S.]]
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[[Category: bovine pancrea]]
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[[Category: Bovine pancrea]]
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[[Category: crystal]]
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[[Category: Crystal]]
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[[Category: domain swapping]]
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[[Category: Domain swapping]]
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[[Category: ribonuclease]]
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[[Category: Ribonuclease]]
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[[Category: structure]]
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[[Category: Structure]]
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[[Category: x-ray]]
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[[Category: X-ray]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:52:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:13:35 2008''
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Revision as of 10:52, 30 April 2008

Image:1f0v.gif

Template:STRUCTURE 1f0v

Crystal structure of an Rnase A dimer displaying a new type of 3D domain swapping


Overview

Bovine pancreatic ribonuclease (RNase A) forms two types of dimers (a major and a minor component) upon concentration in mild acid. These two dimers exhibit different biophysical and biochemical properties. Earlier we reported that the minor dimer forms by swapping its N-terminal alpha-helix with that of an identical molecule. Here we find that the major dimer forms by swapping its C-terminal beta-strand, thus revealing the first example of three-dimensional (3D) domain swapping taking place in different parts of the same protein. This feature permits RNase A to form tightly bonded higher oligomers. The hinge loop of the major dimer, connecting the swapped beta-strand to the protein core, resembles a short segment of the polar zipper proposed by Perutz and suggests a model for aggregate formation by 3D domain swapping with a polar zipper.

About this Structure

1F0V is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

A domain-swapped RNase A dimer with implications for amyloid formation., Liu Y, Gotte G, Libonati M, Eisenberg D, Nat Struct Biol. 2001 Mar;8(3):211-4. PMID:11224563 Page seeded by OCA on Wed Apr 30 13:52:58 2008

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