1f1m
From Proteopedia
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'''CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN C (OSPC)''' | '''CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN C (OSPC)''' | ||
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[[Category: Kumaran, D.]] | [[Category: Kumaran, D.]] | ||
[[Category: Swaminathan, S.]] | [[Category: Swaminathan, S.]] | ||
| - | [[Category: | + | [[Category: Dimer]] |
| - | [[Category: | + | [[Category: Hb19]] |
| - | [[Category: | + | [[Category: Helical bundle]] |
| - | [[Category: | + | [[Category: Lyme disease]] |
| - | [[Category: | + | [[Category: Ospc]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:46:54 2008'' | |
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Revision as of 12:46, 2 May 2008
CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN C (OSPC)
Overview
Outer surface protein C (OspC) is a major antigen on the surface of the Lyme disease spirochete, Borrelia burgdorferi, when it is being transmitted to humans. Crystal structures of OspC have been determined for strains HB19 and B31 to 1.8 and 2.5 A resolution, respectively. The three-dimensional structure is predominantly helical. This is in contrast to the structure of OspA, a major surface protein mainly present when spirochetes are residing in the midgut of unfed ticks, which is mostly beta-sheet. The surface of OspC that would project away from the spirochete's membrane has a region of strong negative electrostatic potential which may be involved in binding to positively charged host ligands. This feature is present only on OspCs from strains known to cause invasive human disease.
About this Structure
1F1M is a Single protein structure of sequence from Borrelia burgdorferi. Full crystallographic information is available from OCA.
Reference
Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi., Kumaran D, Eswaramoorthy S, Luft BJ, Koide S, Dunn JJ, Lawson CL, Swaminathan S, EMBO J. 2001 Mar 1;20(5):971-8. PMID:11230121 Page seeded by OCA on Fri May 2 15:46:54 2008
