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1vmp

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Revision as of 07:44, 4 April 2018

STRUCTURE OF THE ANTI-HIV CHEMOKINE VMIP-II

Structural highlights

1vmp is a 1 chain structure with sequence from Hhv-8. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[VMI2_HHV8P] Blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors. May form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

We report the solution structure of the chemotactic cytokine (chemokine) vMIP-II. This protein has unique biological activities in that it blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors, some of which are used by HJV to gain cell entry. vMIP-II is a monomeric protein, unlike most members of the chemokine family, and its structure consists of a disordered N-terminus, followed by a helical turn (Gln25-Leu27), which leads into the first strand of a three-stranded antiparallel beta-sheet (Ser29-Thr34; Gly42-Thr47; Gln52-Asp56). Following the sheet is a C-terminal alpha-helix, which extends from residue Asp60 until Gln68. The final five residues beyond the C-terminal helix (Pro70-Arg74) are in an extended conformation, but several of these C-terminal residues contact the first beta-strand. The structure of vMIP-II is compared to other chemokines that also block infection by HIV-1, and the structural basis of its lack of ability to form a dimer is discussed.

The solution structure of the anti-HIV chemokine vMIP-II.,Liwang AC, Wang ZX, Sun Y, Peiper SC, Liwang PJ Protein Sci. 1999 Nov;8(11):2270-80. PMID:10595530^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Liwang AC, Wang ZX, Sun Y, Peiper SC, Liwang PJ. The solution structure of the anti-HIV chemokine vMIP-II. Protein Sci. 1999 Nov;8(11):2270-80. PMID:10595530

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1vmp"

@@ Line 1: / Line 1: @@
 ==STRUCTURE OF THE ANTI-HIV CHEMOKINE VMIP-II==
 <StructureSection load='1vmp' size='340' side='right' caption='[[1vmp]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[1vmp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-8 Hhv-8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VMP FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vmp OCA], [http://pdbe.org/1vmp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vmp RCSB], [http://www.ebi.ac.uk/pdbsum/1vmp PDBsum]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vmp OCA], [http://pdbe.org/1vmp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vmp RCSB], [http://www.ebi.ac.uk/pdbsum/1vmp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vmp ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 11: / Line 12: @@
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vm/1vmp_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vm/1vmp_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 39: / Line 40: @@
 [[Category: Chemokine]]
 [[Category: Herpesvirus]]
-[[Category: Kaposis']]
+[[Category: Kaposes']]
 [[Category: Monomer]]
 [[Category: Sarcoma]]
 [[Category: Vmip-ii]]

1vmp

From Proteopedia

Revision as of 07:44, 4 April 2018

STRUCTURE OF THE ANTI-HIV CHEMOKINE VMIP-II

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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