1f34

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[[Image:1f34.gif|left|200px]]
[[Image:1f34.gif|left|200px]]
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{{Structure
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|PDB= 1f34 |SIZE=350|CAPTION= <scene name='initialview01'>1f34</scene>, resolution 2.45&Aring;
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The line below this paragraph, containing "STRUCTURE_1f34", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pepsin_A Pepsin A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.1 3.4.23.1] </span>
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{{STRUCTURE_1f34| PDB=1f34 | SCENE= }}
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|RELATEDENTRY=[[1f32|1F32]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f34 OCA], [http://www.ebi.ac.uk/pdbsum/1f34 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1f34 RCSB]</span>
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'''CRYSTAL STRUCTURE OF ASCARIS PEPSIN INHIBITOR-3 BOUND TO PORCINE PEPSIN'''
'''CRYSTAL STRUCTURE OF ASCARIS PEPSIN INHIBITOR-3 BOUND TO PORCINE PEPSIN'''
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[[Category: Ng, K K.]]
[[Category: Ng, K K.]]
[[Category: Petersen, J F.]]
[[Category: Petersen, J F.]]
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[[Category: proteinase-inhibitor complex]]
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[[Category: Proteinase-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:50:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:14:49 2008''
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Revision as of 12:50, 2 May 2008

Image:1f34.gif

Template:STRUCTURE 1f34

CRYSTAL STRUCTURE OF ASCARIS PEPSIN INHIBITOR-3 BOUND TO PORCINE PEPSIN


Overview

The three-dimensional structures of pepsin inhibitor-3 (PI-3) from Ascaris suum and of the complex between PI-3 and porcine pepsin at 1. 75 A and 2.45 A resolution, respectively, have revealed the mechanism of aspartic protease inhibition by this unique inhibitor. PI-3 has a new fold consisting of two domains, each comprising an antiparallel beta-sheet flanked by an alpha-helix. In the enzyme-inhibitor complex, the N-terminal beta-strand of PI-3 pairs with one strand of the 'active site flap' (residues 70-82) of pepsin, thus forming an eight-stranded beta-sheet that spans the two proteins. PI-3 has a novel mode of inhibition, using its N-terminal residues to occupy and therefore block the first three binding pockets in pepsin for substrate residues C-terminal to the scissile bond (S1'-S3'). The molecular structure of the pepsin-PI-3 complex suggests new avenues for the rational design of proteinaceous aspartic proteinase inhibitors.

About this Structure

1F34 is a Protein complex structure of sequences from Ascaris suum and Sus scrofa. Full crystallographic information is available from OCA.

Reference

Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3., Ng KK, Petersen JF, Cherney MM, Garen C, Zalatoris JJ, Rao-Naik C, Dunn BM, Martzen MR, Peanasky RJ, James MN, Nat Struct Biol. 2000 Aug;7(8):653-7. PMID:10932249 Page seeded by OCA on Fri May 2 15:50:07 2008

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