1f3c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1f3c.jpg|left|200px]]
[[Image:1f3c.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1f3c |SIZE=350|CAPTION= <scene name='initialview01'>1f3c</scene>
+
The line below this paragraph, containing "STRUCTURE_1f3c", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1f3c| PDB=1f3c | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f3c OCA], [http://www.ebi.ac.uk/pdbsum/1f3c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1f3c RCSB]</span>
+
-
}}
+
'''REFINED SOLUTION STRUCTURE OF 8KDA DYNEIN LIGHT CHAIN (DLC8)'''
'''REFINED SOLUTION STRUCTURE OF 8KDA DYNEIN LIGHT CHAIN (DLC8)'''
Line 19: Line 16:
==About this Structure==
==About this Structure==
-
1F3C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. This structure supersedes the now removed PDB entry 1BKQ. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F3C OCA].
+
1F3C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bkq 1bkq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F3C OCA].
==Reference==
==Reference==
Line 29: Line 26:
[[Category: Zhang, M.]]
[[Category: Zhang, M.]]
[[Category: Zhang, Q.]]
[[Category: Zhang, Q.]]
-
[[Category: dlc8]]
+
[[Category: Dlc8]]
-
[[Category: dynein]]
+
[[Category: Dynein]]
-
[[Category: light chain]]
+
[[Category: Light chain]]
-
[[Category: microtubule]]
+
[[Category: Microtubule]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:50:35 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:14:58 2008''
+

Revision as of 12:50, 2 May 2008

Image:1f3c.jpg

Template:STRUCTURE 1f3c

REFINED SOLUTION STRUCTURE OF 8KDA DYNEIN LIGHT CHAIN (DLC8)


Overview

Dyneins are multi-subunit molecular motors that translocate molecular cargoes along microtubules. Other than acting as an essential component of the dynein motor complex, the 89-residue subunit of dynein light chain (DLC8) also regulates a number of other biological events by binding to various proteins and enzymes. Currently known DLC8 targets include neuronal nitric oxide synthase; the proapoptotic Bcl-2 family member protein designated Bim; a Drosophila RNA localization protein Swallow, myosin V, neuronal scaffolding protein GKAP, and IkappaBalpha, an inhibitor of the NFkappaB transcription factor. The DLC8-binding domains of the various targets are confined within a short, continuous stretch of amino acid residues. However, these domains do not share any obvious sequence homology with each other. Here, the three-dimensional structures of DLC8 complexed with two peptides corresponding to the DLC8-binding domains of neuronal nitric oxide synthase and Bim, respectively, were determined by NMR spectroscopy. Although the two DLC8-binding peptides have entirely different amino acid sequences, both peptides bind to the protein with a remarkable similar conformation by engaging the symmetric DLC8 dimer through antiparallel beta-sheet augmentation via the beta2 strand of the protein. Structural comparison indicates that the two target peptides use different regions within the conformational flexible peptide-binding channels to achieve binding specificity. We have also re-determined the apo-form solution structure of DLC8 in this work. The structures of the DLC8/target peptide complexes, together with the dynamic properties of the protein, provide a molecular basis of DLC8's diverse amino acid sequence-dependent target recognition.

About this Structure

1F3C is a Single protein structure of sequence from Rattus norvegicus. This structure supersedes the now removed PDB entry 1bkq. Full crystallographic information is available from OCA.

Reference

Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain., Fan J, Zhang Q, Tochio H, Li M, Zhang M, J Mol Biol. 2001 Feb 9;306(1):97-108. PMID:11178896 Page seeded by OCA on Fri May 2 15:50:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1f3c"
Personal tools