1f59

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[[Image:1f59.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f59 OCA], [http://www.ebi.ac.uk/pdbsum/1f59 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1f59 RCSB]</span>
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'''IMPORTIN-BETA-FXFG NUCLEOPORIN COMPLEX'''
'''IMPORTIN-BETA-FXFG NUCLEOPORIN COMPLEX'''
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[[Category: Littlewood, T.]]
[[Category: Littlewood, T.]]
[[Category: Stewart, M.]]
[[Category: Stewart, M.]]
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[[Category: protein-protein complex]]
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[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:55:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:16:09 2008''
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Revision as of 12:55, 2 May 2008

Image:1f59.gif

Template:STRUCTURE 1f59

IMPORTIN-BETA-FXFG NUCLEOPORIN COMPLEX


Overview

We describe the crystal structure of a complex between importin-beta residues 1-442 (Ib442) and five FxFG nucleoporin repeats from Nsp1p. Nucleoporin FxFG cores bind on the convex face of Ib442 to a primary site between the A helices of HEAT repeats 5 and 6, and to a secondary site between HEAT repeats 6 and 7. Mutations at importin-beta Ile178 in the primary FxFG binding site reduce both binding and nuclear protein import, providing direct evidence for the functional significance of the importin-beta-FxFG interaction. The FxFG binding sites on importin-beta do not overlap with the RanGTP binding site. Instead, RanGTP may release importin-beta from FxFG nucleoporins by generating a conformational change that alters the structure of the FxFG binding site.

About this Structure

1F59 is a Single protein structure of sequence from Homo sapiens and Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking., Bayliss R, Littlewood T, Stewart M, Cell. 2000 Jul 7;102(1):99-108. PMID:10929717 Page seeded by OCA on Fri May 2 15:55:11 2008

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