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2qjx

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Revision as of 09:50, 18 October 2017

Structural Basis of Microtubule Plus End Tracking by XMAP215, CLIP-170 and EB1

Structural highlights

2qjx is a 1 chain structure with sequence from Atcc 18824. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Related:	2qjz, 2qk0, 2qk1, 2qk2
Gene:	BIM1 (ATCC 18824)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BIM1_YEAST] Binds microtubules.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Microtubule plus end binding proteins (+TIPs) localize to the dynamic plus ends of microtubules, where they stimulate microtubule growth and recruit signaling molecules. Three main +TIP classes have been identified (XMAP215, EB1, and CLIP-170), but whether they act upon microtubule plus ends through a similar mechanism has not been resolved. Here, we report crystal structures of the tubulin binding domains of XMAP215 (yeast Stu2p and Drosophila Msps), EB1 (yeast Bim1p and human EB1), and CLIP-170 (human), which reveal diverse tubulin binding interfaces. Functional studies, however, reveal a common property that native or artificial dimerization of tubulin binding domains (including chemically induced heterodimers of EB1 and CLIP-170) induces tubulin nucleation/assembly in vitro and, in most cases, plus end tracking in living cells. We propose that +TIPs, although diverse in structure, share a common property of multimerizing tubulin, thus acting as polymerization chaperones that aid in subunit addition to the microtubule plus end.

Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1.,Slep KC, Vale RD Mol Cell. 2007 Sep 21;27(6):976-91. PMID:17889670^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Slep KC, Vale RD. Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1. Mol Cell. 2007 Sep 21;27(6):976-91. PMID:17889670 doi:10.1016/j.molcel.2007.07.023

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2qjx"

Categories: Atcc 18824 | Slep, K C | Vale, R D | Calponin homology domain | Protein binding

@@ Line 1: / Line 1: @@
 ==Structural Basis of Microtubule Plus End Tracking by XMAP215, CLIP-170 and EB1==
 <StructureSection load='2qjx' size='340' side='right' caption='[[2qjx]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
@@ Line 6: / Line 7: @@
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2qjz|2qjz]], [[2qk0|2qk0]], [[2qk1|2qk1]], [[2qk2|2qk2]]</td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BIM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjx OCA], [http://pdbe.org/2qjx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qjx RCSB], [http://www.ebi.ac.uk/pdbsum/2qjx PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjx OCA], [http://pdbe.org/2qjx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qjx RCSB], [http://www.ebi.ac.uk/pdbsum/2qjx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qjx ProSAT]</span></td></tr>
 </table>
 == Function ==

2qjx

From Proteopedia

Revision as of 09:50, 18 October 2017

Structural Basis of Microtubule Plus End Tracking by XMAP215, CLIP-170 and EB1

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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