1f7y

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[[Image:1f7y.gif|left|200px]]
[[Image:1f7y.gif|left|200px]]
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{{Structure
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|PDB= 1f7y |SIZE=350|CAPTION= <scene name='initialview01'>1f7y</scene>, resolution 2.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1f7y", creates the "Structure Box" on the page.
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{{STRUCTURE_1f7y| PDB=1f7y | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f7y OCA], [http://www.ebi.ac.uk/pdbsum/1f7y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1f7y RCSB]</span>
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'''THE CRYSTAL STRUCTURE OF TWO UUCG LOOPS HIGHLIGHTS THE ROLE PLAYED BY 2'-HYDROXYL GROUPS IN ITS UNUSUAL STABILITY'''
'''THE CRYSTAL STRUCTURE OF TWO UUCG LOOPS HIGHLIGHTS THE ROLE PLAYED BY 2'-HYDROXYL GROUPS IN ITS UNUSUAL STABILITY'''
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[[Category: Serganov, A.]]
[[Category: Serganov, A.]]
[[Category: Tishchenko, S.]]
[[Category: Tishchenko, S.]]
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[[Category: ribosome]]
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[[Category: Ribosome]]
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[[Category: rna]]
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[[Category: Rna]]
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[[Category: tetraloop]]
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[[Category: Tetraloop]]
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[[Category: uucg]]
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[[Category: Uucg]]
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[[Category: x-ray]]
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[[Category: X-ray]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:00:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:17:44 2008''
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Revision as of 13:00, 2 May 2008

Image:1f7y.gif

Template:STRUCTURE 1f7y

THE CRYSTAL STRUCTURE OF TWO UUCG LOOPS HIGHLIGHTS THE ROLE PLAYED BY 2'-HYDROXYL GROUPS IN ITS UNUSUAL STABILITY


Overview

All large structured RNAs contain hairpin motifs made of a stem closed by several looped nucleotides. The most frequent loop motif is the UUCG one. This motif belongs to the tetraloop family and has the peculiarity of being highly thermodynamically stable. Here, we report the first crystal structure of two UUCG tetraloops embedded in a larger RNA-protein complex solved at 2.8 A resolution. The two loops present in the asymmetric unit are in a different crystal packing environment but, nevertheless, have an identical conformation. The observed structure is globally close to that obtained in solution by nuclear magnetic resonance. However, subtle differences point to a more detailed picture of the role played by 2'-hydroxyl groups in stabilising this tetraloop.

About this Structure

1F7Y is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

The crystal structure of UUCG tetraloop., Ennifar E, Nikulin A, Tishchenko S, Serganov A, Nevskaya N, Garber M, Ehresmann B, Ehresmann C, Nikonov S, Dumas P, J Mol Biol. 2000 Nov 17;304(1):35-42. PMID:11071808 Page seeded by OCA on Fri May 2 16:00:43 2008

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