1f85
From Proteopedia
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'''SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIIE''' | '''SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIIE''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F85 OCA]. | |
==Reference== | ==Reference== | ||
Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function., Lukavsky PJ, Otto GA, Lancaster AM, Sarnow P, Puglisi JD, Nat Struct Biol. 2000 Dec;7(12):1105-10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11101890 11101890] | Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function., Lukavsky PJ, Otto GA, Lancaster AM, Sarnow P, Puglisi JD, Nat Struct Biol. 2000 Dec;7(12):1105-10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11101890 11101890] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Lancaster, A M.]] | [[Category: Lancaster, A M.]] | ||
[[Category: Lukavsky, P J.]] | [[Category: Lukavsky, P J.]] | ||
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[[Category: Puglisi, J D.]] | [[Category: Puglisi, J D.]] | ||
[[Category: Sarnow, P.]] | [[Category: Sarnow, P.]] | ||
| - | [[Category: | + | [[Category: Hairpin loop]] |
| - | [[Category: | + | [[Category: Hepatitis c virus internal ribosome entry site]] |
| - | [[Category: | + | [[Category: Ribonucleic acid]] |
| - | [[Category: | + | [[Category: Rna structure]] |
| - | [[Category: | + | [[Category: Tetraloop]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:00:59 2008'' | |
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Revision as of 13:01, 2 May 2008
SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIIE
Overview
Translation of the hepatitis C virus (HCV) polyprotein is initiated at an internal ribosome entry site (IRES) element in the 5' untranslated region of HCV RNA. The HCV IRES element interacts directly with the 40S subunit, and biochemical experiments have implicated RNA elements near the AUG start codon as required for IRES-40S subunit complex formation. The data we present here show that two RNA stem loops, domains IIId and IIIe, are involved in IRES-40S subunit interaction. The structures of the two RNA domains were solved by NMR spectroscopy and reveal structural features that may explain their role in IRES function.
About this Structure
Full crystallographic information is available from OCA.
Reference
Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function., Lukavsky PJ, Otto GA, Lancaster AM, Sarnow P, Puglisi JD, Nat Struct Biol. 2000 Dec;7(12):1105-10. PMID:11101890 Page seeded by OCA on Fri May 2 16:00:59 2008
