1fad

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1fad.gif|left|200px]]
[[Image:1fad.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1fad |SIZE=350|CAPTION= <scene name='initialview01'>1fad</scene>
+
The line below this paragraph, containing "STRUCTURE_1fad", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1fad| PDB=1fad | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fad OCA], [http://www.ebi.ac.uk/pdbsum/1fad PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fad RCSB]</span>
+
-
}}
+
'''DEATH DOMAIN OF FAS-ASSOCIATED DEATH DOMAIN PROTEIN, RESIDUES 89-183'''
'''DEATH DOMAIN OF FAS-ASSOCIATED DEATH DOMAIN PROTEIN, RESIDUES 89-183'''
Line 31: Line 28:
[[Category: Park, Y I.]]
[[Category: Park, Y I.]]
[[Category: Sim, W S.]]
[[Category: Sim, W S.]]
-
[[Category: apoptosis]]
+
[[Category: Apoptosis]]
-
[[Category: death domain]]
+
[[Category: Death domain]]
-
[[Category: fadd]]
+
[[Category: Fadd]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:05:55 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:19:01 2008''
+

Revision as of 13:05, 2 May 2008

Image:1fad.gif

Template:STRUCTURE 1fad

DEATH DOMAIN OF FAS-ASSOCIATED DEATH DOMAIN PROTEIN, RESIDUES 89-183


Overview

A signal of Fas-mediated apoptosis is transferred through an adaptor protein Fas-associated death domain protein (FADD) by interactions between the death domains of Fas and FADD. To understand the signal transduction mechanism of Fas-mediated apoptosis, we solved the solution structure of a murine FADD death domain. It consists of six helices arranged in a similar fold to the other death domains. The interactions between the death domains of Fas and FADD analyzed by site-directed mutagenesis indicate that charged residues in helices alpha2 and alpha3 are involved in death domain interactions, and the interacting helices appear to interact in anti-parallel pattern, alpha2 of FADD with alpha3 of Fas and vice versa.

About this Structure

1FAD is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The solution structure of FADD death domain. Structural basis of death domain interactions of Fas and FADD., Jeong EJ, Bang S, Lee TH, Park YI, Sim WS, Kim KS, J Biol Chem. 1999 Jun 4;274(23):16337-42. PMID:10347191 Page seeded by OCA on Fri May 2 16:05:55 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fad"
Personal tools