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'''THE STRUCTURE OF AN HIV-1 SPECIFIC CELL ENTRY INHIBITOR IN COMPLEX WITH THE HIV-1 GP41 TRIMERIC CORE'''
'''THE STRUCTURE OF AN HIV-1 SPECIFIC CELL ENTRY INHIBITOR IN COMPLEX WITH THE HIV-1 GP41 TRIMERIC CORE'''
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[[Category: Wiley, D C.]]
[[Category: Wiley, D C.]]
[[Category: Zhou, G.]]
[[Category: Zhou, G.]]
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[[Category: gp41]]
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[[Category: Gp41]]
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[[Category: hiv-1]]
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[[Category: Hiv-1]]
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[[Category: inhibitor]]
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[[Category: Inhibitor]]
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Revision as of 13:06, 2 May 2008

Image:1fav.jpg

Template:STRUCTURE 1fav

THE STRUCTURE OF AN HIV-1 SPECIFIC CELL ENTRY INHIBITOR IN COMPLEX WITH THE HIV-1 GP41 TRIMERIC CORE


Overview

The three-dimensional structure of the complex between an HIV-1 cell-entry inhibitor selected from screening a combinatorial library of non-natural building blocks and the central, trimeric, coiled-coil core of HIV-1 gp41 has been determined by X-ray crystallography. The biased combinatorial library was designed to identify ligands binding in nonpolar pockets on the surface of the coiled-coil core of gp41. The crystal structure shows that the non-peptide moiety of the inhibitor binds to the targeted cavity in two different binding modes. This result suggests a strategy for increasing inhibitor potency by use of a second-generation combinatorial library designed to give simultaneous occupancy of both binding sites.

About this Structure

1FAV is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

The structure of an HIV-1 specific cell entry inhibitor in complex with the HIV-1 gp41 trimeric core., Zhou G, Ferrer M, Chopra R, Kapoor TM, Strassmaier T, Weissenhorn W, Skehel JJ, Oprian D, Schreiber SL, Harrison SC, Wiley DC, Bioorg Med Chem. 2000 Sep;8(9):2219-27. PMID:11026535 Page seeded by OCA on Fri May 2 16:06:56 2008

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