1fat

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[[Image:1fat.gif|left|200px]]
[[Image:1fat.gif|left|200px]]
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{{Structure
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|PDB= 1fat |SIZE=350|CAPTION= <scene name='initialview01'>1fat</scene>, resolution 2.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1fat", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=CAA:Ca+Binding+Site+In+Chain+A'>CAA</scene>, <scene name='pdbsite=CAB:Ca+Binding+Site+In+Chain+B'>CAB</scene>, <scene name='pdbsite=CAC:Ca+Binding+Site+In+Chain+C'>CAC</scene>, <scene name='pdbsite=CAD:Ca+Binding+Site+In+Chain+D'>CAD</scene>, <scene name='pdbsite=MNA:Mn+Binding+Site+In+Chain+A'>MNA</scene>, <scene name='pdbsite=MNB:Mn+Binding+Site+In+Chain+B'>MNB</scene>, <scene name='pdbsite=MNC:Mn+Binding+Site+In+Chain+C'>MNC</scene> and <scene name='pdbsite=MND:Mn+Binding+Site+In+Chain+D'>MND</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_1fat| PDB=1fat | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fat OCA], [http://www.ebi.ac.uk/pdbsum/1fat PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fat RCSB]</span>
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}}
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'''PHYTOHEMAGGLUTININ-L'''
'''PHYTOHEMAGGLUTININ-L'''
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[[Category: Hamelryck, T.]]
[[Category: Hamelryck, T.]]
[[Category: Loris, R.]]
[[Category: Loris, R.]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: lectin]]
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[[Category: Lectin]]
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[[Category: plant defense protein]]
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[[Category: Plant defense protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:06:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:19:19 2008''
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Revision as of 13:06, 2 May 2008

Image:1fat.gif

Template:STRUCTURE 1fat

PHYTOHEMAGGLUTININ-L


Overview

The structure of phytohemagglutinin-L (PHA-L), a leucoagglutinating seed lectin from Phaseolus vulgaris, has been solved with molecular replacement using the coordinates of lentil lectin as model, and refined at a resolution of 2.8 A. The final R-factor of the structure is 20.0%. The quaternary structure of the PHA-L tetramer differs from the structures of the concanavalin A and peanut lectin tetramers, but resembles the structure of the soybean agglutinin tetramer. PHA-L consists of two canonical legume lectin dimers that pack together through the formation of a close contact between two beta-strands. Of the two covalently bound oligosaccharides per monomer, only one GlcNAc residue per monomer is visible in the electron density. In this article we describe the structure of PHA-L, and we discuss the putative position of the high affinity adenine-binding site present in a number of legume lectins. A comparison with transthyretin, a protein that shows a remarkable resemblance to PHA-L, gives further ground to our proposal.

About this Structure

1FAT is a Single protein structure of sequence from Phaseolus vulgaris. Full crystallographic information is available from OCA.

Reference

The crystallographic structure of phytohemagglutinin-L., Hamelryck TW, Dao-Thi MH, Poortmans F, Chrispeels MJ, Wyns L, Loris R, J Biol Chem. 1996 Aug 23;271(34):20479-85. PMID:8702788 Page seeded by OCA on Fri May 2 16:06:48 2008

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OCA

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