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2v2x

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-==T CELL CROSS-REACTIVITY AND CONFORMATIONAL CHANGES DURING TCR ENGAGEMENT.==
+==T cell cross-reactivity and conformational changes during TCR engagement.==
 <StructureSection load='2v2x' size='340' side='right' caption='[[2v2x]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[2v2x]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2bsv 2bsv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V2X FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1akj|1akj]], [[1ao7|1ao7]], [[1aqd|1aqd]], [[1b0g|1b0g]], [[1b0r|1b0r]], [[1bd2|1bd2]], [[1duy|1duy]], [[1duz|1duz]], [[1eey|1eey]], [[1eez|1eez]], [[1hhg|1hhg]], [[1hhh|1hhh]], [[1hhi|1hhi]], [[1hhj|1hhj]], [[1hhk|1hhk]], [[1hla|1hla]], [[1i1f|1i1f]], [[1i1y|1i1y]], [[1i4f|1i4f]], [[1i7r|1i7r]], [[1i7t|1i7t]], [[1i7u|1i7u]], [[1im3|1im3]], [[1jf1|1jf1]], [[1jht|1jht]], [[1lp9|1lp9]], [[1oga|1oga]], [[1p7q|1p7q]], [[1qew|1qew]], [[1qr1|1qr1]], [[1qrn|1qrn]], [[1qse|1qse]], [[1qsf|1qsf]], [[1s8d|1s8d]], [[1s9w|1s9w]], [[1s9x|1s9x]], [[1s9y|1s9y]], [[1t1w|1t1w]], [[1t1x|1t1x]], [[1t1y|1t1y]], [[1t1z|1t1z]], [[1t20|1t20]], [[1t21|1t21]], [[1t22|1t22]], [[1tvb|1tvb]], [[1tvh|1tvh]], [[1ur7|1ur7]], [[2av1|2av1]], [[2av7|2av7]], [[2bnq|2bnq]], [[2bnr|2bnr]], [[2bsu|2bsu]], [[2bsv|2bsv]], [[2c7u|2c7u]], [[2clr|2clr]], [[2gj6|2gj6]], [[2jcc|2jcc]], [[2uwe|2uwe]], [[3hla|3hla]], [[1a1m|1a1m]], [[1a1n|1a1n]], [[1a1o|1a1o]], [[1a6z|1a6z]], [[1a9b|1a9b]], [[1a9e|1a9e]], [[1agb|1agb]], [[1agc|1agc]], [[1agd|1agd]], [[1age|1age]], [[1agf|1agf]], [[1c16|1c16]], [[1ce6|1ce6]], [[1cg9|1cg9]], [[1de4|1de4]], [[1e27|1e27]], [[1e28|1e28]], [[1efx|1efx]], [[1exu|1exu]], [[1gzp|1gzp]], [[1gzq|1gzq]], [[1hsa|1hsa]], [[1hsb|1hsb]], [[1im9|1im9]], [[1jgd|1jgd]], [[1jge|1jge]], [[1jnj|1jnj]], [[1k5n|1k5n]], [[1kpr|1kpr]], [[1ktl|1ktl]], [[1lds|1lds]], [[1m05|1m05]], [[1m6o|1m6o]], [[1mhe|1mhe]], [[1mi5|1mi5]], [[1n2r|1n2r]], [[1of2|1of2]], [[1ogt|1ogt]], [[1onq|1onq]], [[1py4|1py4]], [[1q94|1q94]], [[1qlf|1qlf]], [[1qqd|1qqd]], [[1qvo|1qvo]], [[1r3h|1r3h]], [[1sys|1sys]], [[1syv|1syv]], [[1tmc|1tmc]], [[1uqs|1uqs]], [[1uxs|1uxs]], [[1uxw|1uxw]], [[1vgk|1vgk]], [[1w0v|1w0v]], [[1w0w|1w0w]], [[1w72|1w72]], [[1x7q|1x7q]], [[1xh3|1xh3]], [[1xr8|1xr8]], [[1xr9|1xr9]], [[1xz0|1xz0]], [[1ydp|1ydp]], [[1ypz|1ypz]], [[1zs8|1zs8]], [[1zsd|1zsd]], [[1zt4|1zt4]], [[2a83|2a83]], [[2ak4|2ak4]], [[2axf|2axf]], [[2axg|2axg]], [[2bck|2bck]], [[2bsr|2bsr]], [[2bss|2bss]], [[2bst|2bst]], [[2bvq|2bvq]], [[2cii|2cii]], [[2cik|2cik]], [[2d31|2d31]], [[2esv|2esv]], [[2f74|2f74]], [[2f8o|2f8o]], [[2h26|2h26]], [[2hjk|2hjk]], [[2hjl|2hjl]], [[2hla|2hla]], [[2v2w|2v2w]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2x OCA], [http://pdbe.org/2v2x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v2x RCSB], [http://www.ebi.ac.uk/pdbsum/2v2x PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2x OCA], [http://pdbe.org/2v2x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v2x RCSB], [http://www.ebi.ac.uk/pdbsum/2v2x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2x ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 12: / Line 13: @@
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v2x_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v2x_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 40: / Line 41: @@
 [[Category: Douek, D C]]
 [[Category: Gleria, K Di]]
-[[Category: Harlos, K]]
 [[Category: Jones, E Y]]
 [[Category: Lee, J K]]
-[[Category: Mcmichael, A J]]
+[[Category: McMichael, A J]]
-[[Category: Merwe, P A.Van Der]]
+[[Category: Merwe, P A.van der]]
 [[Category: Stewart-Jones, G]]
+[[Category: Harlos, K]]
 [[Category: Disease mutation]]
 [[Category: Glycoprotein]]
@@ Line 55: / Line 56: @@
 [[Category: Mhc i]]
 [[Category: Mhc tcr hla-a2 hiv]]
+[[Category: Polymorphism]]
 [[Category: Pyrrolidone carboxylic acid]]
 [[Category: Transmembrane]]
+[[Category: Ubl conjugation]]

Revision as of 08:10, 12 September 2018

T cell cross-reactivity and conformational changes during TCR engagement.

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2v2x, resolution 1.60Å

Show:Asymmetric Unit Biological Assembly

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Structural highlights

2v2x is a 6 chain structure with sequence from Human. This structure supersedes the now removed PDB entry 2bsv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1akj, 1ao7, 1aqd, 1b0g, 1b0r, 1bd2, 1duy, 1duz, 1eey, 1eez, 1hhg, 1hhh, 1hhi, 1hhj, 1hhk, 1hla, 1i1f, 1i1y, 1i4f, 1i7r, 1i7t, 1i7u, 1im3, 1jf1, 1jht, 1lp9, 1oga, 1p7q, 1qew, 1qr1, 1qrn, 1qse, 1qsf, 1s8d, 1s9w, 1s9x, 1s9y, 1t1w, 1t1x, 1t1y, 1t1z, 1t20, 1t21, 1t22, 1tvb, 1tvh, 1ur7, 2av1, 2av7, 2bnq, 2bnr, 2bsu, 2bsv, 2c7u, 2clr, 2gj6, 2jcc, 2uwe, 3hla, 1a1m, 1a1n, 1a1o, 1a6z, 1a9b, 1a9e, 1agb, 1agc, 1agd, 1age, 1agf, 1c16, 1ce6, 1cg9, 1de4, 1e27, 1e28, 1efx, 1exu, 1gzp, 1gzq, 1hsa, 1hsb, 1im9, 1jgd, 1jge, 1jnj, 1k5n, 1kpr, 1ktl, 1lds, 1m05, 1m6o, 1mhe, 1mi5, 1n2r, 1of2, 1ogt, 1onq, 1py4, 1q94, 1qlf, 1qqd, 1qvo, 1r3h, 1sys, 1syv, 1tmc, 1uqs, 1uxs, 1uxw, 1vgk, 1w0v, 1w0w, 1w72, 1x7q, 1xh3, 1xr8, 1xr9, 1xz0, 1ydp, 1ypz, 1zs8, 1zsd, 1zt4, 2a83, 2ak4, 2axf, 2axg, 2bck, 2bsr, 2bss, 2bst, 2bvq, 2cii, 2cik, 2d31, 2esv, 2f74, 2f8o, 2h26, 2hjk, 2hjl, 2hla, 2v2w
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[1A02_HUMAN] Involved in the presentation of foreign antigens to the immune system.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

All thymically selected T cells are inherently cross-reactive, yet many data indicate a fine specificity in antigen recognition, which enables virus escape from immune control by mutation in infections such as the human immunodeficiency virus (HIV). To address this paradox, we analyzed the fine specificity of T cells recognizing a human histocompatibility leukocyte antigen (HLA)-A2-restricted, strongly immunodominant, HIV gag epitope (SLFNTVATL). The majority of 171 variant peptides tested bound HLA-A2, but only one third were recognized. Surprisingly, one recognized variant (SLYNTVATL) showed marked differences in structure when bound to HLA-A2. T cell receptor (TCR) recognition of variants of these two peptides implied that they adopted the same conformation in the TCR-peptide-major histocompatibility complex (MHC) complex. However, the on-rate kinetics of TCR binding were identical, implying that conformational changes at the TCR-peptide-MHC binding interface occur after an initial permissive antigen contact. These findings have implications for the rational design of vaccines targeting viruses with unstable genomes.

T cell cross-reactivity and conformational changes during TCR engagement.,Lee JK, Stewart-Jones G, Dong T, Harlos K, Di Gleria K, Dorrell L, Douek DC, van der Merwe PA, Jones EY, McMichael AJ J Exp Med. 2004 Dec 6;200(11):1455-66. PMID:15583017^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Lee JK, Stewart-Jones G, Dong T, Harlos K, Di Gleria K, Dorrell L, Douek DC, van der Merwe PA, Jones EY, McMichael AJ. T cell cross-reactivity and conformational changes during TCR engagement. J Exp Med. 2004 Dec 6;200(11):1455-66. PMID:15583017 doi:http://dx.doi.org/10.1084/jem.20041251

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

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OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2v2x"

2v2x

From Proteopedia

Revision as of 08:10, 12 September 2018

T cell cross-reactivity and conformational changes during TCR engagement.

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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