1fbp

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[[Image:1fbp.jpg|left|200px]]
[[Image:1fbp.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1fbp |SIZE=350|CAPTION= <scene name='initialview01'>1fbp</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1fbp", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1fbp| PDB=1fbp | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fbp OCA], [http://www.ebi.ac.uk/pdbsum/1fbp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fbp RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH FRUCTOSE 6-PHOSPHATE, AMP, AND MAGNESIUM'''
'''CRYSTAL STRUCTURE OF FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH FRUCTOSE 6-PHOSPHATE, AMP, AND MAGNESIUM'''
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[[Category: Lipscomb, W N.]]
[[Category: Lipscomb, W N.]]
[[Category: Zhang, Y.]]
[[Category: Zhang, Y.]]
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[[Category: hydrolase (phosphoric monoester)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:08:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:19:45 2008''
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Revision as of 13:08, 2 May 2008

Image:1fbp.jpg

Template:STRUCTURE 1fbp

CRYSTAL STRUCTURE OF FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH FRUCTOSE 6-PHOSPHATE, AMP, AND MAGNESIUM


Overview

The crystal structure of fructose-1,6-bisphosphatase (EC 3.1.3.11) complexed with fructose 6-phosphate, AMP, and Mg2+ has been solved by the molecular replacement method and refined at 2.5-A resolution to a R factor of 0.215, with root-mean-square deviations of 0.013 A and 3.5 degrees for bond lengths and bond angles, respectively. No solvent molecules have been included in the refinement. This structure shows large quaternary and tertiary conformational changes from the structures of the unligated enzyme or its fructose 2,6-bisphosphate complex, but the secondary structures remain essentially the same. Dimer C3-C4 of the enzyme-fructose 6-phosphate-AMP-Mg2+ complex twists about 19 degrees relative to the same dimer of the enzyme-fructose 2,6-bisphosphate complex if their C1-C2 dimers are superimposed on one another. Nevertheless, many interfacial interactions between dimers of C1-C2 and C3-C4 are conserved after quaternary structure changes occur. Residues of the AMP domain (residues 6-200) show large migrations of C alpha atoms relative to barely significant positional changes of the FBP domain (residues 201-335).

About this Structure

1FBP is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Crystal structure of fructose-1,6-bisphosphatase complexed with fructose 6-phosphate, AMP, and magnesium., Ke HM, Zhang YP, Lipscomb WN, Proc Natl Acad Sci U S A. 1990 Jul;87(14):5243-7. PMID:2164670 Page seeded by OCA on Fri May 2 16:08:28 2008

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