1fd9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1fd9.jpg|left|200px]]
[[Image:1fd9.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1fd9 |SIZE=350|CAPTION= <scene name='initialview01'>1fd9</scene>, resolution 2.41&Aring;
+
The line below this paragraph, containing "STRUCTURE_1fd9", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1fd9| PDB=1fd9 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fd9 OCA], [http://www.ebi.ac.uk/pdbsum/1fd9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fd9 RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF THE MACROPHAGE INFECTIVITY POTENTIATOR PROTEIN (MIP) A MAJOR VIRULENCE FACTOR FROM LEGIONELLA PNEUMOPHILA'''
'''CRYSTAL STRUCTURE OF THE MACROPHAGE INFECTIVITY POTENTIATOR PROTEIN (MIP) A MAJOR VIRULENCE FACTOR FROM LEGIONELLA PNEUMOPHILA'''
Line 33: Line 30:
[[Category: Rahfeld, J.]]
[[Category: Rahfeld, J.]]
[[Category: Riboldi-Tunnicliffe, A.]]
[[Category: Riboldi-Tunnicliffe, A.]]
-
[[Category: dimerisation via helical interaction]]
+
[[Category: Dimerisation via helical interaction]]
-
[[Category: fkbp domain]]
+
[[Category: Fkbp domain]]
-
[[Category: long alpha helix]]
+
[[Category: Long alpha helix]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:11:46 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:20:38 2008''
+

Revision as of 13:11, 2 May 2008

Image:1fd9.jpg

Template:STRUCTURE 1fd9

CRYSTAL STRUCTURE OF THE MACROPHAGE INFECTIVITY POTENTIATOR PROTEIN (MIP) A MAJOR VIRULENCE FACTOR FROM LEGIONELLA PNEUMOPHILA


Overview

The human pathogen Legionella pneumophila, the etiological agent of the severe and often fatal Legionnaires' disease, produces a major virulence factor, termed 'macrophage infectivity potentiator protein' (Mip), that is necessary for optimal multiplication of the bacteria within human alveolar macrophages. Mip exhibits a peptidyl prolyl cis-trans isomerase (PPIase) activity, which appears to be important for infection. Here we report the 2.4 A crystal structure of the Mip protein from L. pneumophila Philadelphia 1 and the 3.2 A crystal structure of its complex with the drug FK506. Each monomer of the homodimeric protein consists of an N-terminal dimerization module, a long (65 A) connecting alpha-helix and a C-terminal PPIase domain exhibiting similarity to human FK506-binding protein. In view of the recent significant increase in the number of reported cases of Legionnaires' disease and other intracellular infections, these structural results are of prime interest for the design of new drugs directed against Mip proteins of intracellular pathogens.

About this Structure

1FD9 is a Single protein structure of sequence from Legionella pneumophila. Full crystallographic information is available from OCA.

Reference

Crystal structure of Mip, a prolylisomerase from Legionella pneumophila., Riboldi-Tunnicliffe A, Konig B, Jessen S, Weiss MS, Rahfeld J, Hacker J, Fischer G, Hilgenfeld R, Nat Struct Biol. 2001 Sep;8(9):779-83. PMID:11524681 Page seeded by OCA on Fri May 2 16:11:46 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fd9"
Personal tools