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1u5l

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Revision as of 08:38, 21 March 2018

Solution Structure of the turtle prion protein fragment (121-226)

Structural highlights

1u5l is a 1 chain structure with sequence from Chrysemys scripta. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	Prnp (Chrysemys scripta)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The NMR structures of the recombinant prion proteins from chicken (Gallus gallus; chPrP), the red-eared slider turtle (Trachemys scripta; tPrP), and the African clawed frog (Xenopus laevis; xlPrP) are presented. The amino acid sequences of these prion proteins show approximately 30% identity with mammalian prion proteins. All three species form the same molecular architecture as mammalian PrPC, with a long, flexibly disordered tail attached to the N-terminal end of a globular domain. The globular domain in chPrP and tPrP contains three alpha-helices, one short 3(10)-helix, and a short antiparallel beta-sheet. In xlPrP, the globular domain includes three alpha-helices and a somewhat longer beta-sheet than in the other species. The spatial arrangement of these regular secondary structures coincides closely with that of the globular domain in mammalian prion proteins. Based on the low sequence identity to mammalian PrPs, comparison of chPrP, tPrP, and xlPrP with mammalian PrPC structures is used to identify a set of essential amino acid positions for the preservation of the same PrPC fold in birds, reptiles, amphibians, and mammals. There are additional conserved residues without apparent structural roles, which are of interest for the ongoing search for physiological functions of PrPC in healthy organisms.

Prion protein NMR structures of chickens, turtles, and frogs.,Calzolai L, Lysek DA, Perez DR, Guntert P, Wuthrich K Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):651-5. Epub 2005 Jan 12. PMID:15647366^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Calzolai L, Lysek DA, Perez DR, Guntert P, Wuthrich K. Prion protein NMR structures of chickens, turtles, and frogs. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):651-5. Epub 2005 Jan 12. PMID:15647366

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1u5l"

@@ Line 1: / Line 1: @@
 ==Solution Structure of the turtle prion protein fragment (121-226)==
 <StructureSection load='1u5l' size='340' side='right' caption='[[1u5l]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
@@ Line 4: / Line 5: @@
 <table><tr><td colspan='2'>[[1u5l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chrysemys_scripta Chrysemys scripta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5L FirstGlance]. <br>
 </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Prnp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=34903 Chrysemys scripta])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5l OCA], [http://pdbe.org/1u5l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u5l RCSB], [http://www.ebi.ac.uk/pdbsum/1u5l PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5l OCA], [http://pdbe.org/1u5l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u5l RCSB], [http://www.ebi.ac.uk/pdbsum/1u5l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5l ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==
@@ Line 10: / Line 11: @@
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u5l_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u5l_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>

1u5l

From Proteopedia

Revision as of 08:38, 21 March 2018

Solution Structure of the turtle prion protein fragment (121-226)

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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