1fft
From Proteopedia
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'''The structure of ubiquinol oxidase from Escherichia coli''' | '''The structure of ubiquinol oxidase from Escherichia coli''' | ||
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[[Category: Svensson-Ek, M.]] | [[Category: Svensson-Ek, M.]] | ||
[[Category: Wikstrom, M.]] | [[Category: Wikstrom, M.]] | ||
| - | [[Category: | + | [[Category: Cytochrome oxidase]] |
| - | [[Category: | + | [[Category: Electron transport]] |
| - | [[Category: | + | [[Category: Membrane protein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:16:27 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 13:16, 2 May 2008
The structure of ubiquinol oxidase from Escherichia coli
Overview
Cell respiration is catalyzed by the heme-copper oxidase superfamily of enzymes, which comprises cytochrome c and ubiquinol oxidases. These membrane proteins utilize different electron donors through dissimilar access mechanisms. We report here the first structure of a ubiquinol oxidase, cytochrome bo3, from Escherichia coli. The overall structure of the enzyme is similar to those of cytochrome c oxidases; however, the membrane-spanning region of subunit I contains a cluster of polar residues exposed to the interior of the lipid bilayer that is not present in the cytochrome c oxidase. Mutagenesis studies on these residues strongly suggest that this region forms a quinone binding site. A sequence comparison of this region with known quinone binding sites in other membrane proteins shows remarkable similarities. In light of these findings we suggest specific roles for these polar residues in electron and proton transfer in ubiquinol oxidase.
About this Structure
1FFT is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.
Reference
The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site., Abramson J, Riistama S, Larsson G, Jasaitis A, Svensson-Ek M, Laakkonen L, Puustinen A, Iwata S, Wikstrom M, Nat Struct Biol. 2000 Oct;7(10):910-7. PMID:11017202 Page seeded by OCA on Fri May 2 16:16:27 2008
