1ffx

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[[Image:1ffx.gif|left|200px]]
[[Image:1ffx.gif|left|200px]]
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{{Structure
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|PDB= 1ffx |SIZE=350|CAPTION= <scene name='initialview01'>1ffx</scene>, resolution 3.95&Aring;
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The line below this paragraph, containing "STRUCTURE_1ffx", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5&#39;-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene>
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{{STRUCTURE_1ffx| PDB=1ffx | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ffx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ffx OCA], [http://www.ebi.ac.uk/pdbsum/1ffx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ffx RCSB]</span>
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'''TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX'''
'''TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX'''
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[[Category: Knossow, M.]]
[[Category: Knossow, M.]]
[[Category: Martin-Barbey, C.]]
[[Category: Martin-Barbey, C.]]
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[[Category: alpha-tubulin]]
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[[Category: Alpha-tubulin]]
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[[Category: beta-tubulin]]
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[[Category: Beta-tubulin]]
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[[Category: microtubule]]
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[[Category: Microtubule]]
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[[Category: stathmin]]
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[[Category: Stathmin]]
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[[Category: tubulin]]
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[[Category: Tubulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:16:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:22:13 2008''
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Revision as of 13:16, 2 May 2008

Image:1ffx.gif

Template:STRUCTURE 1ffx

TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX


Overview

Phosphoproteins of the stathmin family interact with the alphabeta tubulin heterodimer (tubulin) and hence interfere with microtubule dynamics. The structure of the complex of GDP-tubulin with the stathmin-like domain of the neural protein RB3 reveals a head-to-tail assembly of two tubulins with a 91-residue RB3 alpha helix in which each copy of an internal duplicated sequence interacts with a different tubulin. As a result of the relative orientations adopted by tubulins and by their alpha and beta subunits, the tubulin:RB3 complex forms a curved structure. The RB3 helix thus most likely prevents incorporation of tubulin into microtubules by holding it in an assembly with a curvature very similar to that of the depolymerization products of microtubules.

About this Structure

1FFX is a Protein complex structure of sequences from Bos taurus and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The 4 A X-ray structure of a tubulin:stathmin-like domain complex., Gigant B, Curmi PA, Martin-Barbey C, Charbaut E, Lachkar S, Lebeau L, Siavoshian S, Sobel A, Knossow M, Cell. 2000 Sep 15;102(6):809-16. PMID:11030624 Page seeded by OCA on Fri May 2 16:16:44 2008

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