1fin

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[[Image:1fin.jpg|left|200px]]
[[Image:1fin.jpg|left|200px]]
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{{Structure
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|PDB= 1fin |SIZE=350|CAPTION= <scene name='initialview01'>1fin</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1fin", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>
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{{STRUCTURE_1fin| PDB=1fin | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fin OCA], [http://www.ebi.ac.uk/pdbsum/1fin PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fin RCSB]</span>
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'''CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX'''
'''CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX'''
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[[Category: Pavletich, N P.]]
[[Category: Pavletich, N P.]]
[[Category: Russo, A A.]]
[[Category: Russo, A A.]]
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[[Category: cdk]]
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[[Category: Cdk]]
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[[Category: complex (transferase/cyclin)]]
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[[Category: Cyclin]]
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[[Category: cyclin]]
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[[Category: Phosphorylation]]
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[[Category: phosphorylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:22:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:23:38 2008''
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Revision as of 13:22, 2 May 2008

Image:1fin.jpg

Template:STRUCTURE 1fin

CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX


Overview

The crystal structure of the human cyclinA-cyclin-dependent kinase2 (CDK2)-ATP complex has been determined at 2.3 A resolution. CyclinA binds to one side of CDK2's catalytic cleft, inducing large conformational changes in its PSTAIRE helix and T-loop. These changes activate the kinase by realigning active site residues and relieving the steric blockade at the entrance of the catalytic cleft.

About this Structure

1FIN is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex., Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz J, Massague J, Pavletich NP, Nature. 1995 Jul 27;376(6538):313-20. PMID:7630397 Page seeded by OCA on Fri May 2 16:22:19 2008

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