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1fmk

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[[Image:1fmk.gif|left|200px]]
[[Image:1fmk.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1fmk |SIZE=350|CAPTION= <scene name='initialview01'>1fmk</scene>, resolution 1.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1fmk", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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|DOMAIN=
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{{STRUCTURE_1fmk| PDB=1fmk | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fmk OCA], [http://www.ebi.ac.uk/pdbsum/1fmk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fmk RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC'''
'''CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC'''
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[[Category: Harrison, S C.]]
[[Category: Harrison, S C.]]
[[Category: Xu, W.]]
[[Category: Xu, W.]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: phosphotransferase]]
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[[Category: Phosphotransferase]]
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[[Category: phosphotyrosine]]
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[[Category: Phosphotyrosine]]
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[[Category: proto-oncogene]]
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[[Category: Proto-oncogene]]
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[[Category: sh2]]
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[[Category: Sh2]]
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[[Category: sh3]]
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[[Category: Sh3]]
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[[Category: src]]
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[[Category: Src]]
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[[Category: tyrosine kinase]]
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[[Category: Tyrosine kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:30:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:25:53 2008''
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Revision as of 13:30, 2 May 2008

Image:1fmk.gif

Template:STRUCTURE 1fmk

CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC


Overview

The structure of a large fragment of the c-Src tyrosine kinase, comprising the regulatory and kinase domains and the carboxy-terminal tall, has been determined at 1.7 A resolution in a closed, inactive state. Interactions among domains, stabilized by binding of the phosphorylated tail to the SH2 domain, lock the molecule in a conformation that simultaneously disrupts the kinase active site and sequesters the binding surfaces of the SH2 and SH3 domains. The structure shows how appropriate cellular signals, or transforming mutations in v-Src, could break these interactions to produce an open, active kinase.

About this Structure

1FMK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the tyrosine kinase c-Src., Xu W, Harrison SC, Eck MJ, Nature. 1997 Feb 13;385(6617):595-602. PMID:9024657 Page seeded by OCA on Fri May 2 16:30:20 2008

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