1fmq

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[[Image:1fmq.gif|left|200px]]
[[Image:1fmq.gif|left|200px]]
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{{Structure
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|PDB= 1fmq |SIZE=350|CAPTION= <scene name='initialview01'>1fmq</scene>, resolution 2.&Aring;
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The line below this paragraph, containing "STRUCTURE_1fmq", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=D34:2,5-BIS{[4-(N-CYCLOBUTYLDIAMINOMETHYL)PHENYL]}FURAN'>D34</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1fmq| PDB=1fmq | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fmq OCA], [http://www.ebi.ac.uk/pdbsum/1fmq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fmq RCSB]</span>
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'''Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG'''
'''Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG'''
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==About this Structure==
==About this Structure==
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1FMQ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMQ OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMQ OCA].
==Reference==
==Reference==
DNA minor groove interactions and the biological activity of 2,5-bis., Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S, Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11128631 11128631]
DNA minor groove interactions and the biological activity of 2,5-bis., Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S, Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11128631 11128631]
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[[Category: Protein complex]]
 
[[Category: Boykin, D W.]]
[[Category: Boykin, D W.]]
[[Category: Kumar, A.]]
[[Category: Kumar, A.]]
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[[Category: Neidle, S.]]
[[Category: Neidle, S.]]
[[Category: Simpson, I J.]]
[[Category: Simpson, I J.]]
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[[Category: dna-drug minor groove complex]]
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[[Category: Dna-drug minor groove complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:30:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:25:59 2008''
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Revision as of 13:30, 2 May 2008

Image:1fmq.gif

Template:STRUCTURE 1fmq

Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG


Overview

2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against Pneumocystis carinii and also show cytotoxicity against several tumour cell lines. These activities are correlated with DNA-binding abilities; the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG) is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds.

About this Structure

Full crystallographic information is available from OCA.

Reference

DNA minor groove interactions and the biological activity of 2,5-bis., Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S, Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:11128631 Page seeded by OCA on Fri May 2 16:30:48 2008

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