This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1fpx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1fpx.jpg|left|200px]]
[[Image:1fpx.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1fpx |SIZE=350|CAPTION= <scene name='initialview01'>1fpx</scene>, resolution 1.65&Aring;
+
The line below this paragraph, containing "STRUCTURE_1fpx", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1fpx| PDB=1fpx | SCENE= }}
-
|RELATEDENTRY=[[1fp1|1FP1]], [[1fp2|1FP2]], [[1fpq|1FPQ]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fpx OCA], [http://www.ebi.ac.uk/pdbsum/1fpx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fpx RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE ANALYSIS OF SELENOMETHIONINE SUBSTITUTED ISOFLAVONE O-METHYLTRANSFERASE'''
'''CRYSTAL STRUCTURE ANALYSIS OF SELENOMETHIONINE SUBSTITUTED ISOFLAVONE O-METHYLTRANSFERASE'''
Line 28: Line 25:
[[Category: Noel, J P.]]
[[Category: Noel, J P.]]
[[Category: Zubieta, C.]]
[[Category: Zubieta, C.]]
-
[[Category: s-adenosymethionine complex]]
+
[[Category: S-adenosymethionine complex]]
-
[[Category: selenomethionine]]
+
[[Category: Selenomethionine]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:37:35 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:28:02 2008''
+

Revision as of 13:37, 2 May 2008

Image:1fpx.jpg

Template:STRUCTURE 1fpx

CRYSTAL STRUCTURE ANALYSIS OF SELENOMETHIONINE SUBSTITUTED ISOFLAVONE O-METHYLTRANSFERASE


Overview

Chalcone O-methyltransferase (ChOMT) and isoflavone O-methyltransferase (IOMT) are S-adenosyl-l-methionine (SAM) dependent plant natural product methyltransferases involved in secondary metabolism in Medicago sativa (alfalfa). Here we report the crystal structure of ChOMT in complex with the product S-adenosyl-l-homocysteine and the substrate isoliquiritigenin (4,2',4'-trihydroxychalcone) refined to 1.8 A as well as the crystal structure of IOMT in complex with the products S-adenosyl-l-homocysteine and isoformononetin (4'-hydroxy-7-methoxyisoflavone) refined to 1.4 A. These two OMTs constitute the first plant methyltransferases to be structurally characterized and reveal a novel oligomerization domain and the molecular determinants for substrate selection. As such, this work provides a structural basis for understanding the substrate specificity of the diverse family of plant OMTs and facilitates the engineering of novel activities in this extensive class of natural product biosynthetic enzymes.

About this Structure

1FPX is a Single protein structure of sequence from Medicago sativa. Full crystallographic information is available from OCA.

Reference

Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases., Zubieta C, He XZ, Dixon RA, Noel JP, Nat Struct Biol. 2001 Mar;8(3):271-9. PMID:11224575 Page seeded by OCA on Fri May 2 16:37:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fpx"
Personal tools