This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4pi3
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| + | |||
==Crystal structure analysis of cruzain bound to vinyl sulfone analog of WRR-483 (WRR-666)== | ==Crystal structure analysis of cruzain bound to vinyl sulfone analog of WRR-483 (WRR-666)== | ||
| - | <StructureSection load='4pi3' size='340' side='right' caption='[[4pi3]], [[Resolution|resolution]] 1.27Å' scene=''> | + | <StructureSection load='4pi3' size='340' side='right'caption='[[4pi3]], [[Resolution|resolution]] 1.27Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4pi3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PI3 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4pi3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PI3 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2V5:N-[(2S)-5-(CARBAMIMIDAMIDOOXY)-1-OXO-1-{[(1E,3S)-5-PHENYL-1-(PHENYLSULFONYL)PENT-1-EN-3-YL]AMINO}PENTAN-2-YL]-4-METHYLPIPERAZINE-1-CARBOXAMIDE'>2V5</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2V5:N-[(2S)-5-(CARBAMIMIDAMIDOOXY)-1-OXO-1-{[(1E,3S)-5-PHENYL-1-(PHENYLSULFONYL)PENT-1-EN-3-YL]AMINO}PENTAN-2-YL]-4-METHYLPIPERAZINE-1-CARBOXAMIDE'>2V5</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lxs|3lxs]], [[2oz2|2oz2]], [[4xui|4xui]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lxs|3lxs]], [[2oz2|2oz2]], [[4xui|4xui]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cruzipain Cruzipain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.51 3.4.22.51] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cruzipain Cruzipain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.51 3.4.22.51] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pi3 OCA], [http://pdbe.org/4pi3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pi3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pi3 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pi3 OCA], [http://pdbe.org/4pi3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pi3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pi3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pi3 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| Line 19: | Line 20: | ||
</div> | </div> | ||
<div class="pdbe-citations 4pi3" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4pi3" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Cruzain|Cruzain]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 24: | Line 28: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Cruzipain]] | [[Category: Cruzipain]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Trycr]] | ||
[[Category: McKerrow, J H]] | [[Category: McKerrow, J H]] | ||
[[Category: Tochowicz, A]] | [[Category: Tochowicz, A]] | ||
Revision as of 07:20, 17 April 2019
Crystal structure analysis of cruzain bound to vinyl sulfone analog of WRR-483 (WRR-666)
| |||||||||||
