Bromodomain-containing protein
From Proteopedia
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'''Bromodomain-containing proteins''' (BRD) are active as histone acetyltransferase, chromatin remodeling and transcriptional mediation. The bromodomain is a ca. 110 amino acid long sequence which recognizes acetylated lysine residues which are found in the C-terminal of histones. | '''Bromodomain-containing proteins''' (BRD) are active as histone acetyltransferase, chromatin remodeling and transcriptional mediation. The bromodomain is a ca. 110 amino acid long sequence which recognizes acetylated lysine residues which are found in the C-terminal of histones. | ||
| - | <ref>PMID:21638687</ref> | + | <ref>PMID:21638687</ref> |
For detalis on BRD3 see [[Human bromodomain containing protein 3]] | For detalis on BRD3 see [[Human bromodomain containing protein 3]] | ||
== Disease == | == Disease == | ||
| - | Dysfunction of BRD is involved in cancer, inflammation and multiple sclerosis. | + | Dysfunction of BRD is involved in cancer, inflammation, obesity and multiple sclerosis<ref>PMID:22722403</ref>. |
== Relevance == | == Relevance == | ||
Revision as of 09:43, 10 February 2016
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3D Structures of bromodomain-containing protein
Updated on 10-February-2016
References
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Belkina AC, Denis GV. BET domain co-regulators in obesity, inflammation and cancer. Nat Rev Cancer. 2012 Jun 22;12(7):465-77. doi: 10.1038/nrc3256. PMID:22722403 doi:http://dx.doi.org/10.1038/nrc3256
