This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2n9q
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Photoswitchable G-quadruplex== | |
| + | <StructureSection load='2n9q' size='340' side='right' caption='[[2n9q]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2n9q]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N9Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N9Q FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZW:4-{(E)-[4-(HYDROXYMETHYL)PHENYL]DIAZENYL}BENZYL+DIHYDROGEN+PHOSPHATE'>AZW</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n9q OCA], [http://pdbe.org/2n9q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n9q RCSB], [http://www.ebi.ac.uk/pdbsum/2n9q PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The ability of three different bifunctional azobenzene linkers to enable the photoreversible formation of a defined intermolecular two-tetrad G-quadruplex upon UV/Vis irradiation was investigated. Circular dichroism and NMR spectroscopic data showed the formation of G-quadruplexes with K(+) ions at room temperature in all three cases with the corresponding azobenzene linker in an E conformation. However, only the para-para-substituted azobenzene derivative enables photoswitching between a nonpolymorphic, stacked, tetramolecular G-quadruplex and an unstructured state after E-Z isomerization. | ||
| - | + | Photoresponsive Formation of an Intermolecular Minimal G-Quadruplex Motif.,Thevarpadam J, Bessi I, Binas O, Goncalves DP, Slavov C, Jonker HR, Richter C, Wachtveitl J, Schwalbe H, Heckel A Angew Chem Int Ed Engl. 2016 Feb;55(8):2738-42. doi: 10.1002/anie.201510269. Epub, 2016 Jan 25. PMID:26805928<ref>PMID:26805928</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2n9q" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | + | ||
[[Category: Bessi, I]] | [[Category: Bessi, I]] | ||
| - | [[Category: | + | [[Category: Binas, O]] |
| + | [[Category: Goncalves, D P.N]] | ||
[[Category: Heckel, A]] | [[Category: Heckel, A]] | ||
| + | [[Category: Jonker, H R.A]] | ||
| + | [[Category: Richter, C]] | ||
| + | [[Category: Schwalbe, H]] | ||
| + | [[Category: Slavov, C]] | ||
| + | [[Category: Thevarpadam, J]] | ||
| + | [[Category: Wachtveitl, J]] | ||
| + | [[Category: Dna]] | ||
| + | [[Category: Photoswitch]] | ||
| + | [[Category: Quadruplex]] | ||
Revision as of 02:38, 21 February 2016
Photoswitchable G-quadruplex
| |||||||||||
Categories: Bessi, I | Binas, O | Goncalves, D P.N | Heckel, A | Jonker, H R.A | Richter, C | Schwalbe, H | Slavov, C | Thevarpadam, J | Wachtveitl, J | Dna | Photoswitch | Quadruplex
