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2na2

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'''Unreleased structure'''
 
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The entry 2na2 is ON HOLD until Paper Publication
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==DROSHA QUAD MUTANT DOUBLE-STRANDED RNA BINDING COMPETENT==
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<StructureSection load='2na2' size='340' side='right' caption='[[2na2]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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Authors: Showalter, S.A., Sahu, D., Kranick, J.C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2na2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NA2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NA2 FirstGlance]. <br>
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Description: DROSHA QUAD MUTANT DOUBLE-STRANDED RNA BINDING COMPETENT
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2na2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2na2 OCA], [http://pdbe.org/2na2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2na2 RCSB], [http://www.ebi.ac.uk/pdbsum/2na2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2na2 ProSAT]</span></td></tr>
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[[Category: Kranick, J.C]]
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</table>
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[[Category: Showalter, S.A]]
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== Function ==
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[[http://www.uniprot.org/uniprot/RNC_HUMAN RNC_HUMAN]] Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.<ref>PMID:10948199</ref> <ref>PMID:14508493</ref> <ref>PMID:15589161</ref> <ref>PMID:15574589</ref> <ref>PMID:15531877</ref> <ref>PMID:15565168</ref> <ref>PMID:16751099</ref> <ref>PMID:16906129</ref> <ref>PMID:17159994</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Ribonuclease III]]
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[[Category: Kranick, J C]]
[[Category: Sahu, D]]
[[Category: Sahu, D]]
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[[Category: Showalter, S A]]
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[[Category: Drosha]]
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[[Category: Hydrolase]]
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[[Category: Nuclear protein-rna binding protein complex]]

Revision as of 21:35, 22 December 2016

DROSHA QUAD MUTANT DOUBLE-STRANDED RNA BINDING COMPETENT

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