Cyclophilin
From Proteopedia
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== Relevance == | == Relevance == | ||
| - | Cyp-A has a key role in immunosuppression and viral infection. Cyp-A is the target of the immunosuppressant cyclosporin A whose binding leads to the suppression of the T-cell mediated immune response. Cyp-A is required for effective HIV-1 replication in host cells. | + | Cyp-A has a key role in immunosuppression and viral infection<ref>PMID:22814107</ref>. Cyp-A is the target of the immunosuppressant cyclosporin A whose binding leads to the suppression of the T-cell mediated immune response. Cyp-A is required for effective HIV-1 replication in host cells<ref>PMID:15596813</ref>. |
== Structural highlights == | == Structural highlights == | ||
Revision as of 09:11, 6 April 2017
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3D Structures of Cyclophilin
Updated on 06-April-2017
References
- ↑ Stamnes MA, Rutherford SL, Zuker CS. Cyclophilins: a new family of proteins involved in intracellular folding. Trends Cell Biol. 1992 Sep;2(9):272-6. PMID:14731520
- ↑ Zhou D, Mei Q, Li J, He H. Cyclophilin A and viral infections. Biochem Biophys Res Commun. 2012 Aug 10;424(4):647-50. doi:, 10.1016/j.bbrc.2012.07.024. Epub 2012 Jul 16. PMID:22814107 doi:http://dx.doi.org/10.1016/j.bbrc.2012.07.024
- ↑ Hatziioannou T, Perez-Caballero D, Cowan S, Bieniasz PD. Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells. J Virol. 2005 Jan;79(1):176-83. PMID:15596813 doi:http://dx.doi.org/10.1128/JVI.79.1.176-183.2005
- ↑ Lammers M, Neumann H, Chin JW, James LC. Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. Nat Chem Biol. 2010 May;6(5):331-7. Epub 2010 Apr 4. PMID:20364129 doi:10.1038/nchembio.342
