1fui

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[[Image:1fui.gif|left|200px]]
[[Image:1fui.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1fui |SIZE=350|CAPTION= <scene name='initialview01'>1fui</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1fui", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FOC:FUCITOL'>FOC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Arabinose_isomerase Arabinose isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.3 5.3.1.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= FUCI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_1fui| PDB=1fui | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fui OCA], [http://www.ebi.ac.uk/pdbsum/1fui PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fui RCSB]</span>
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}}
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'''L-FUCOSE ISOMERASE FROM ESCHERICHIA COLI'''
'''L-FUCOSE ISOMERASE FROM ESCHERICHIA COLI'''
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[[Category: Schulz, G E.]]
[[Category: Schulz, G E.]]
[[Category: Seemann, J E.]]
[[Category: Seemann, J E.]]
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[[Category: fucose metabolism]]
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[[Category: Fucose metabolism]]
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[[Category: isomerase]]
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[[Category: Isomerase]]
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[[Category: ketol isomerase]]
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[[Category: Ketol isomerase]]
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[[Category: l-fucose to l-fuculose conversion]]
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[[Category: L-fucose to l-fuculose conversion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:46:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:30:33 2008''
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Revision as of 13:46, 2 May 2008

Image:1fui.gif

Template:STRUCTURE 1fui

L-FUCOSE ISOMERASE FROM ESCHERICHIA COLI


Overview

The three-dimensional structure of L-fucose isomerase from Escherichia coli has been determined by X-ray crystallography at 2.5 A resolution. This ketol isomerase converts the aldose L-fucose into the corresponding ketose L-fuculose using Mn2+ as a cofactor. Being a hexamer with 64,976 Da per subunit, L-fucose isomerase is the largest structurally known ketol isomerase. The enzyme shows neither sequence nor structural similarity with other ketol isomerases. The hexamer obeys D3 symmetry and forms the crystallographic asymmetric unit. The strict and favorably oriented local symmetry allowed for a computational phase extension from 7.3 A to 2.5 A resolution. The structure was solved with an L-fucitol molecule bound to the catalytic center such that the hydroxyl groups at positions 1 and 2 are ligands of the manganese ion. Most likely, L-fucitol mimics a bound L-fucose molecule in its open chain form. The protein environment suggests strongly that the reaction belongs to the ene-diol type.

About this Structure

1FUI is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of L-fucose isomerase from Escherichia coli., Seemann JE, Schulz GE, J Mol Biol. 1997 Oct 17;273(1):256-68. PMID:9367760 Page seeded by OCA on Fri May 2 16:46:45 2008

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OCA

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