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5f9s

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'''Unreleased structure'''
 
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The entry 5f9s is ON HOLD until Paper Publication
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==Crystal structure of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) at 1.7 Angstrom; internal aldimine with PLP in the active site==
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<StructureSection load='5f9s' size='340' side='right' caption='[[5f9s]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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Authors: Giardina, G., Cutruzzola, F., Borri Voltattorni, C., Cellini, B., Montioli, R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5f9s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F9S FirstGlance]. <br>
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Description: Crystal structure of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) at 1.7 Angstrom; internal aldimine with PLP in the active site
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f9s OCA], [http://pdbe.org/5f9s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f9s RCSB], [http://www.ebi.ac.uk/pdbsum/5f9s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f9s ProSAT]</span></td></tr>
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[[Category: Borri Voltattorni, C]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/SPYA_HUMAN SPYA_HUMAN]] Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1) [MIM:[http://omim.org/entry/259900 259900]]; also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract.<ref>PMID:1703535</ref> <ref>PMID:2039493</ref> <ref>PMID:1349575</ref> <ref>PMID:1301173</ref> <ref>PMID:8101040</ref> <ref>PMID:9192270</ref> <ref>PMID:9604803</ref> <ref>PMID:10394939</ref> <ref>PMID:10453743</ref> <ref>PMID:10541294</ref> <ref>PMID:10862087</ref> <ref>PMID:10960483</ref> <ref>PMID:12559847</ref> <ref>PMID:12777626</ref> <ref>PMID:15253729</ref> <ref>PMID:15849466</ref> <ref>PMID:15961946</ref> <ref>PMID:15963748</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Cellini, B]]
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[[Category: Cutruzzola, F]]
[[Category: Giardina, G]]
[[Category: Giardina, G]]
[[Category: Montioli, R]]
[[Category: Montioli, R]]
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[[Category: Cutruzzola, F]]
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[[Category: Voltattorni, C Borri]]
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[[Category: Cellini, B]]
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[[Category: Aminotransferase]]
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[[Category: Detoxification]]
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[[Category: Liver]]
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[[Category: Transferase]]

Revision as of 21:37, 22 December 2016

Crystal structure of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) at 1.7 Angstrom; internal aldimine with PLP in the active site

5f9s, resolution 1.70Å

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