5fup

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5fup is ON HOLD
+
==Crystal structure of human JARID1B in complex with 2-oxoglutarate.==
-
 
+
<StructureSection load='5fup' size='340' side='right' caption='[[5fup]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
-
Authors: Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Talon, R., Von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5fup]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FUP FirstGlance]. <br>
-
Description: Crystal structure of human JARID1B in complex with 2-oxoglutarate.
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fv3|5fv3]]</td></tr>
-
[[Category: Nowak, R]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fup OCA], [http://pdbe.org/5fup PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fup RCSB], [http://www.ebi.ac.uk/pdbsum/5fup PDBsum]</span></td></tr>
-
[[Category: Burgess-Brown, N.A]]
+
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bountra, C]]
 +
[[Category: Burgess-Brown, N A]]
 +
[[Category: Delft, F Von]]
 +
[[Category: Edwards, A M]]
 +
[[Category: Gileadi, C]]
 +
[[Category: Johansson, C]]
[[Category: Kupinska, K]]
[[Category: Kupinska, K]]
-
[[Category: Arrowsmith, C.H]]
+
[[Category: Nowak, R]]
-
[[Category: Gileadi, C]]
+
[[Category: Oppermann, U]]
[[Category: Oppermann, U]]
 +
[[Category: Srikannathasan, V]]
 +
[[Category: Strain-Damerell, C]]
[[Category: Szykowska, A]]
[[Category: Szykowska, A]]
-
[[Category: Von Delft, F]]
 
-
[[Category: Edwards, A.M]]
 
[[Category: Talon, R]]
[[Category: Talon, R]]
-
[[Category: Johansson, C]]
+
[[Category: Jarid1b]]
-
[[Category: Strain-Damerell, C]]
+
[[Category: Oxidoreductase]]
-
[[Category: Srikannathasan, V]]
+
[[Category: Plu1]]

Revision as of 13:05, 11 May 2016

Crystal structure of human JARID1B in complex with 2-oxoglutarate.

5fup, resolution 2.15Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5fup"
Personal tools