5hza
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of GII.10 P domain in complex with 3-fucosyllactose (3 FL)== | |
| + | <StructureSection load='5hza' size='340' side='right' caption='[[5hza]], [[Resolution|resolution]] 1.35Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5hza]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HZA FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hza OCA], [http://pdbe.org/5hza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hza RCSB], [http://www.ebi.ac.uk/pdbsum/5hza PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Histo-blood group antigens (HBGAs) are important binding factors for norovirus infections. We show that two human milk oligosaccharides, 2' -fucosyllactose (2' FL) and 3-fucosyllactose (3FL), could block norovirus from binding to surrogate HBGA samples. We found that 2' FL and 3FL bound at the equivalent HBGA pocket on the norovirus capsid using X-ray crystallography. Our data revealed that 2' FL and 3FL structurally mimic HBGAs. These results suggest that 2' FL and 3FL might act as natural-occurring decoys in humans. | ||
| - | + | Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides.,Weichert S, Koromyslova A, Singh BK, Hansman S, Jennewein S, Schroten H, Hansman GS J Virol. 2016 Feb 17. pii: JVI.03223-15. PMID:26889023<ref>PMID:26889023</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Koromyslova, A | + | <div class="pdbe-citations 5hza" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Hansman, G S]] | ||
| + | [[Category: Koromyslova, A D]] | ||
| + | [[Category: Singh, B K]] | ||
| + | [[Category: 3-fucosyllactose]] | ||
| + | [[Category: Hmo]] | ||
| + | [[Category: Human milk]] | ||
| + | [[Category: Norovirus]] | ||
| + | [[Category: P domain]] | ||
| + | [[Category: Viral protein]] | ||
| + | [[Category: Virus]] | ||
Revision as of 14:57, 2 March 2016
Crystal structure of GII.10 P domain in complex with 3-fucosyllactose (3 FL)
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Categories: Hansman, G S | Koromyslova, A D | Singh, B K | 3-fucosyllactose | Hmo | Human milk | Norovirus | P domain | Viral protein | Virus
