1fwx

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[[Image:1fwx.jpg|left|200px]]
[[Image:1fwx.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1fwx |SIZE=350|CAPTION= <scene name='initialview01'>1fwx</scene>, resolution 1.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1fwx", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CUA:DINUCLEAR+COPPER+ION'>CUA</scene>, <scene name='pdbligand=CUZ:(MU-4-SULFIDO)-TETRA-NUCLEAR+COPPER+ION'>CUZ</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrous-oxide_reductase Nitrous-oxide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.99.6 1.7.99.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1fwx| PDB=1fwx | SCENE= }}
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|RELATEDENTRY=[[1qni|1qni]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fwx OCA], [http://www.ebi.ac.uk/pdbsum/1fwx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fwx RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF NITROUS OXIDE REDUCTASE FROM P. DENITRIFICANS'''
'''CRYSTAL STRUCTURE OF NITROUS OXIDE REDUCTASE FROM P. DENITRIFICANS'''
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[[Category: Saraste, M.]]
[[Category: Saraste, M.]]
[[Category: Tegoni, M.]]
[[Category: Tegoni, M.]]
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[[Category: beta-propeller domain]]
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[[Category: Beta-propeller domain]]
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[[Category: cua site]]
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[[Category: Cua site]]
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[[Category: cupredoxin domain]]
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[[Category: Cupredoxin domain]]
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[[Category: cuz site]]
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[[Category: Cuz site]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:51:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:31:51 2008''
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Revision as of 13:51, 2 May 2008

Image:1fwx.jpg

Template:STRUCTURE 1fwx

CRYSTAL STRUCTURE OF NITROUS OXIDE REDUCTASE FROM P. DENITRIFICANS


Overview

Nitrous-oxide reductases (N2OR) catalyze the two-electron reduction of N(2)O to N(2). The crystal structure of N2ORs from Pseudomonas nautica (Pn) and Paracoccus denitrificans (Pd) were solved at resolutions of 2.4 and 1.6 A, respectively. The Pn N2OR structure revealed that the catalytic CuZ center belongs to a new type of metal cluster in which four copper ions are liganded by seven histidine residues. A bridging oxygen moiety and two other hydroxide ligands were proposed to complete the ligation scheme (Brown, K., Tegoni, M., Prudencio, M., Pereira, A. S., Besson, S., Moura, J. J. G., Moura, I., and Cambillau, C. (2000) Nat. Struct. Biol. 7, 191-195). However, in the CuZ cluster, inorganic sulfur chemical determination and the high resolution structure of Pd N2OR identified a bridging inorganic sulfur instead of an oxygen. This result reconciles the novel CuZ cluster with the hitherto puzzling spectroscopic data.

About this Structure

1FWX is a Single protein structure of sequence from Paracoccus denitrificans. Full crystallographic information is available from OCA.

Reference

Revisiting the catalytic CuZ cluster of nitrous oxide (N2O) reductase. Evidence of a bridging inorganic sulfur., Brown K, Djinovic-Carugo K, Haltia T, Cabrito I, Saraste M, Moura JJ, Moura I, Tegoni M, Cambillau C, J Biol Chem. 2000 Dec 29;275(52):41133-6. PMID:11024061 Page seeded by OCA on Fri May 2 16:51:35 2008

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