5hh3

Publication Abstract from PubMed

Cyclization of glycopeptide antibiotic precursors occurs in either three or four steps catalyzed by Cytochrome P450 enzymes. Three of these enzymes have been structurally characterized to date with the second enzyme along the pathway, OxyA, escaping structural analysis. We are now able to present the structure of OxyAtei involved in teicoplanin biosynthesis - the same enzyme recently shown to be the first active OxyA homologue. In spite of the hydrophobic character of the teicoplanin precursor, the polar active site of OxyAtei and its affinity for certain azole inhibitors hint at its preference for substrates with polar decorations. This article is protected by copyright. All rights reserved.

Structure of OxyA : completing our picture of the glycopeptide antibiotic producing Cytochrome P450 cascade.,Haslinger K, Cryle MJ FEBS Lett. 2016 Jan 28. doi: 10.1002/1873-3468.12081. PMID:26820384^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.