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Kinesin
From Proteopedia
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{{STRUCTURE_2zfi | PDB=2zfi | SIZE=350 | SCENE=Kinesin/Kinesin_start_scene/2 | CAPTION=Kif1A Motor Domain complex with ADP and Mg+2 ion (green), [[2zfi]] }} | {{STRUCTURE_2zfi | PDB=2zfi | SIZE=350 | SCENE=Kinesin/Kinesin_start_scene/2 | CAPTION=Kif1A Motor Domain complex with ADP and Mg+2 ion (green), [[2zfi]] }} | ||
| - | + | == Function == | |
| - | + | ||
| - | + | [[Kinesin|Kinesins]] are eukaryotic motor proteins which move along microtubules. Kinesin (KIF) is a dimer consisting of 2 heavy chains and two light chains. The heavy chain contains the globular motor domain (MD), flexible neck linker (FNL) and a long coiled-coil stalk which intertwines to form the dimer. The light chain (KLC) forms the tail region. The KLC contains a cargo binding domain which is called TPR (Tetratricopeptide repeat). The KIFs are named by their gene number. KIF contains a forkhead-associated domain (FHA) which is involved in phosphopeptide recognition.<br /> | |
| + | *'''Kar3''' is kinesin protein in yeast.<br /> | ||
| + | *'''Eg5''' or '''KIF11''' is a kinesin (See [[Kinesin-5]]) which participates in mitosis.<br /> | ||
| + | *'''KCBP''' is a '''Kinesin-like Calmodulin Binding Protein'''.<br /> | ||
| + | *'''NOD''' is a ''Drosophila'' chromosome-associated kinesin. | ||
| - | + | See also [[CAP-Gly domain]]. | |
== 3D Structures of Kinesin == | == 3D Structures of Kinesin == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *Kinesin heavy chain | + | *Kinesin heavy chain |
**[[2zfi]], [[2zfj]], [[2zfk]], [[2zfl]], [[2zfm]] – mKIF1A – mouse<br /> | **[[2zfi]], [[2zfj]], [[2zfk]], [[2zfl]], [[2zfm]] – mKIF1A – mouse<br /> | ||
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**[[3dco]] - DmNOD catalytic core domain+ cTubulin A+cTubulin B<br /> | **[[3dco]] - DmNOD catalytic core domain+ cTubulin A+cTubulin B<br /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:45, 6 April 2016
Function
Kinesins are eukaryotic motor proteins which move along microtubules. Kinesin (KIF) is a dimer consisting of 2 heavy chains and two light chains. The heavy chain contains the globular motor domain (MD), flexible neck linker (FNL) and a long coiled-coil stalk which intertwines to form the dimer. The light chain (KLC) forms the tail region. The KLC contains a cargo binding domain which is called TPR (Tetratricopeptide repeat). The KIFs are named by their gene number. KIF contains a forkhead-associated domain (FHA) which is involved in phosphopeptide recognition.
- Kar3 is kinesin protein in yeast.
- Eg5 or KIF11 is a kinesin (See Kinesin-5) which participates in mitosis.
- KCBP is a Kinesin-like Calmodulin Binding Protein.
- NOD is a Drosophila chromosome-associated kinesin.
See also CAP-Gly domain.
3D Structures of Kinesin
Updated on 06-April-2016
References
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Michal Harel, Alexander Berchansky, David Canner, Joel L. Sussman, Jaime Prilusky
