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1g3j

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[[Image:1g3j.gif|left|200px]]
[[Image:1g3j.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1g3j| PDB=1g3j | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g3j OCA], [http://www.ebi.ac.uk/pdbsum/1g3j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1g3j RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX'''
'''CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX'''
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[[Category: Weaver, C.]]
[[Category: Weaver, C.]]
[[Category: Xu, W.]]
[[Category: Xu, W.]]
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[[Category: beta-catenin,tcf-3]]
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[[Category: Beta-catenin,tcf-3]]
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[[Category: protein-protein complex]]
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[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:05:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:35:48 2008''
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Revision as of 14:05, 2 May 2008

Image:1g3j.gif

Template:STRUCTURE 1g3j

CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX


Overview

The Wnt signaling pathway plays critical roles in embryonic development and tumorigenesis. Stimulation of the Wnt pathway results in the accumulation of a nuclear beta-catenin/Tcf complex, activating Wnt target genes. A crystal structure of beta-catenin bound to the beta-catenin binding domain of Tcf3 (Tcf3-CBD) has been determined. The Tcf3-CBD forms an elongated structure with three binding modules that runs antiparallel to beta-catenin along the positively charged groove formed by the armadillo repeats. Structure-based mutagenesis defines three sites in beta-catenin that are critical for binding the Tcf3-CBD and are differentially involved in binding APC, cadherin, and Axin. The structural and mutagenesis data reveal a potential target for molecular drug design studies.

About this Structure

1G3J is a Protein complex structure of sequences from Homo sapiens and Xenopus laevis. Full crystallographic information is available from OCA.

Reference

Crystal structure of a beta-catenin/Tcf complex., Graham TA, Weaver C, Mao F, Kimelman D, Xu W, Cell. 2000 Dec 8;103(6):885-96. PMID:11136974 Page seeded by OCA on Fri May 2 17:05:31 2008

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