Sandbox Wabash28
From Proteopedia
(Difference between revisions)
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| - | Serine 195 attacks the scissile bond carbonyl. Ser 195 becomes nucleophilic by base attack from His 57. His 57 will stabilize as a base from aspartic acid and hydrogen bonding. The tetrahedral intermediate collapses back into a carbonyl. | + | Serine 195 attacks the scissile bond carbonyl. Ser 195 becomes nucleophilic by base attack from His 57. His 57 will stabilize as a base from aspartic acid and hydrogen bonding. The tetrahedral intermediate collapses back into a carbonyl. <scene name='72/725339/Stick_substrate/1'>Ser 195</scene> |
== Function == | == Function == | ||
Revision as of 06:40, 15 February 2016
Mechanism of Trypsin (By: Brady Boles, Justin Miller, and Anthony Douglas)
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References
1.↑ Radisky ES, Lee JM, Lu CJ, Koshland DE Jr. Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates. Proc Natl Acad Sci U S A. 2006 May 2;103(18):6835-40. Epub 2006 Apr 24. PMID:16636277
