1g47

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{{Structure
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|GENE= LIMS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g47 OCA], [http://www.ebi.ac.uk/pdbsum/1g47 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1g47 RCSB]</span>
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'''1ST LIM DOMAIN OF PINCH PROTEIN'''
'''1ST LIM DOMAIN OF PINCH PROTEIN'''
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[[Category: Wu, C.]]
[[Category: Wu, C.]]
[[Category: Yang, Y.]]
[[Category: Yang, Y.]]
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[[Category: lim domain]]
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[[Category: Lim domain]]
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[[Category: zn finger]]
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[[Category: Zn finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:07:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:36:18 2008''
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Revision as of 14:07, 2 May 2008

Image:1g47.jpg

Template:STRUCTURE 1g47

1ST LIM DOMAIN OF PINCH PROTEIN


Overview

PINCH is a recently identified adaptor protein that comprises an array of five LIM domains. PINCH functions through LIM-mediated protein-protein interactions that are involved in cell adhesion, growth, and differentiation. The LIM1 domain of PINCH interacts with integrin-linked kinase (ILK), thereby mediating focal adhesions via a specific integrin/ILK signaling pathway. We have solved the NMR structure of the PINCH LIM1 domain and characterized its binding to ILK. LIM1 contains two contiguous zinc fingers of the CCHC and CCCH types and adopts a global fold similar to that of functionally distinct LIM domains from cysteine-rich protein and cysteine-rich intestinal protein families with CCHC and CCCC zinc finger types. Gel-filtration and NMR experiments demonstrated a 1:1 complex between PINCH LIM1 and the ankyrin repeat domain of ILK. A chemical shift mapping experiment identified regions in PINCH LIM1 that are important for interaction with ILK. Comparison of surface features between PINCH LIM1 and other functionally different LIM domains indicated that the LIM motif might have a highly variable mode in recognizing various target proteins.

About this Structure

1G47 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain., Velyvis A, Yang Y, Wu C, Qin J, J Biol Chem. 2001 Feb 16;276(7):4932-9. Epub 2000 Nov 14. PMID:11078733 Page seeded by OCA on Fri May 2 17:07:06 2008

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