Integrin

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<StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrein CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry [[1zoo]])' scene=''>
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<StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrin CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry [[1zoo]])' scene=''>
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== Function ==
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'''Integrins''' (IG) are receptors which mediate the attachment between cells or to extracellular matrix. They are involved in cellular signaling and cell cycle. IGs contain α and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain. For more details see [[Molecular Playground/IntegrinBeta1]].
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'''Integrins''' (IG) are receptors which mediate the attachment between cells and between cells and the extracellular matrix. They are involved in cellular signaling and cell cycle<ref>PMID:10961914</ref>. IGs contain α and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain. For more details see [[Molecular Playground/IntegrinBeta1]].
For some details on the interaction of a targeting peptide with integrin see [[Molecular Playground/Targeting Peptide]].
For some details on the interaction of a targeting peptide with integrin see [[Molecular Playground/Targeting Peptide]].
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==Disease ==
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Defective integrin is the cause of the skin disease epidermolysis bullosa, of congenital muscular dystrophy. Overexpression of integrin is correlated with some types of cancer and enhanced bone resorption in osteoporosis<ref>PMID:8976799</ref>. Defective integrin is involved in periodontal diseases<ref>PMID:24662197</ref>.
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:03, 29 March 2016

Structure of human integrin CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry 1zoo)

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3D structures of integrin

Updated on 29-March-2016

References

  1. ↑ Humphries MJ. Integrin structure. Biochem Soc Trans. 2000;28(4):311-39. PMID:10961914
  2. ↑ Hillis GS, MacLeod AM. Integrins and disease. Clin Sci (Lond). 1996 Dec;91(6):639-50. PMID:8976799
  3. ↑ Larjava H, Koivisto L, Heino J, Hakkinen L. Integrins in periodontal disease. Exp Cell Res. 2014 Jul 15;325(2):104-10. doi: 10.1016/j.yexcr.2014.03.010. Epub, 2014 Mar 22. PMID:24662197 doi:http://dx.doi.org/10.1016/j.yexcr.2014.03.010

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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