Tubulin

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== Function ==
== Function ==
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[[Tubulin]] (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of '''α-tubulin''' (TUBA) and '''β-tubulin''' (TUBB) bound to GTP. See also [[Beta tubulin]]. '''γ-tubulin''' (TUBG) is part of the nucleation of microtubules. Human TUB contains several numbered subtypes. '''FtsZ''' (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB. See also [[Beta tubulin]].
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[[Tubulin]] (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of '''α-tubulin''' (TUBA) and '''β-tubulin''' (TUBB) bound to GTP. See also [[Beta tubulin]]. '''γ-tubulin''' (TUBG) is part of the nucleation of microtubules<ref>PMID:11297925</ref>. Human TUB contains several numbered subtypes. '''FtsZ''' (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB. See also [[Beta tubulin]].
== Relevance ==
== Relevance ==
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The chemotherapeutic drug Taxol interacts with TUBB. See [[Molecular Playground/Taxol]].
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The chemotherapeutic drug Taxol interacts with TUBB. See [[Molecular Playground/Taxol]]. TUBA and TUBB expression in polyps of invasive colon cancer is different from normal<ref>PMID:16101133</ref>.
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== Disease ==
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Mutations in TUBB underlie a large spectrum of neuronal migration disorders<ref>PMID:19465910</ref>.
== 3D Structures of Tubulin ==
== 3D Structures of Tubulin ==
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**[[4m8i]] - SeFtsZ + GDP – ''Staphylococcus epidermitis''<br />
**[[4m8i]] - SeFtsZ + GDP – ''Staphylococcus epidermitis''<br />
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:35, 27 September 2016

Template:STRUCTURE 1z5w

Contents

Function

Tubulin (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of α-tubulin (TUBA) and β-tubulin (TUBB) bound to GTP. See also Beta tubulin. γ-tubulin (TUBG) is part of the nucleation of microtubules[1]. Human TUB contains several numbered subtypes. FtsZ (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB. See also Beta tubulin.

Relevance

The chemotherapeutic drug Taxol interacts with TUBB. See Molecular Playground/Taxol. TUBA and TUBB expression in polyps of invasive colon cancer is different from normal[2].

Disease

Mutations in TUBB underlie a large spectrum of neuronal migration disorders[3].

3D Structures of Tubulin

Updated on 27-September-2016

References

  1. ↑ Moritz M, Agard DA. Gamma-tubulin complexes and microtubule nucleation. Curr Opin Struct Biol. 2001 Apr;11(2):174-81. PMID:11297925
  2. ↑ Giarnieri E, De Francesco GP, Carico E, Midiri G, Amanti C, Giacomelli L, Tucci G, Gidaro S, Stroppa I, Gidaro G, Giovagnoli MR. Alpha- and beta-tubulin expression in rectal cancer development. Anticancer Res. 2005 Sep-Oct;25(5):3237-41. PMID:16101133
  3. ↑ Jaglin XH, Poirier K, Saillour Y, Buhler E, Tian G, Bahi-Buisson N, Fallet-Bianco C, Phan-Dinh-Tuy F, Kong XP, Bomont P, Castelnau-Ptakhine L, Odent S, Loget P, Kossorotoff M, Snoeck I, Plessis G, Parent P, Beldjord C, Cardoso C, Represa A, Flint J, Keays DA, Cowan NJ, Chelly J. Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. Nat Genet. 2009 Jun;41(6):746-52. doi: 10.1038/ng.380. Epub 2009 May 24. PMID:19465910 doi:http://dx.doi.org/10.1038/ng.380

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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