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Factor inhibiting HIF

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Line 21: Line 21:
**[[2cgn]] – hFIH1α + succinate<br />
**[[2cgn]] – hFIH1α + succinate<br />
**[[2cgo]] – hFIH1α + fumarate<br />
**[[2cgo]] – hFIH1α + fumarate<br />
-
**[[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]] – hFIH1α + oxoglutarate derivative<br />
+
**[[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]], [[4z2w]] – hFIH1α + oxoglutarate derivative<br />
**[[3kcx]], [[3kcy]], [[3od4]], [[4bio]] - hFIH1α + quinol derivative<br />
**[[3kcx]], [[3kcy]], [[3od4]], [[4bio]] - hFIH1α + quinol derivative<br />
**[[4ai8]] - hFIH1α + daminozide<br />
**[[4ai8]] - hFIH1α + daminozide<br />
 +
**[[4z1v]] - hFIH1α + oxalylglycine + NO<br />
*FIH1α complex with polypeptide
*FIH1α complex with polypeptide
**[[1h2k]], [[1h2l]], [[1h2m]] – hFIH1α + HIF transactivation domain peptide<br />
**[[1h2k]], [[1h2l]], [[1h2m]] – hFIH1α + HIF transactivation domain peptide<br />
-
**[[2ilm]], [[3d8c]] - hFIH1α (mutant) + HIF peptide + α-ketoglutarate<br />
+
**[[2ilm]], [[3d8c]], [[5jwp]] - hFIH1α (mutant) + HIF peptide + α-ketoglutarate<br />
**[[3p3n]], [[3p3p]] - hFIH1α + Notch 1 peptide<br />
**[[3p3n]], [[3p3p]] - hFIH1α + Notch 1 peptide<br />
**[[2xum]] - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative<br />
**[[2xum]] - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative<br />

Revision as of 08:20, 11 May 2017

Dimeric factor inhibiting HIF complex with oxogluterate derivative (PDB code 1mzf)

Drag the structure with the mouse to rotate

3D Structures of factor inhibiting HIF

Updated on 11-May-2017

References

  1. ↑ Janke K, Brockmeier U, Kuhlmann K, Eisenacher M, Nolde J, Meyer HE, Mairbaurl H, Metzen E. Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2). J Cell Sci. 2013 Jun 15;126(Pt 12):2629-40. doi: 10.1242/jcs.117564. Epub 2013, Apr 19. PMID:23606740 doi:http://dx.doi.org/10.1242/jcs.117564
  2. ↑ Dann CE 3rd, Bruick RK, Deisenhofer J. Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15351-6. Epub 2002 Nov 13. PMID:12432100 doi:http://dx.doi.org/10.1073/pnas.202614999

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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