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Nuclear transcription factor Y

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== Relevance ==
== Relevance ==
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NFY is a regulatory factor for many genes which are overexpressed in many kinds of cancer.
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NFY is a regulatory factor for many genes which are overexpressed in many kinds of cancer<ref>PMID:9095180</ref>.
</StructureSection>
</StructureSection>

Revision as of 08:43, 16 May 2016

Human nuclear transcription factor Y subunit β (grey) and subunit γ(green) (PDB code 1n1j)

Drag the structure with the mouse to rotate

3D Structures of nuclear transcription factor Y

Updated on 16-May-2016

1n1j, 4csr – hNFY β+γ subunits - human
4awl – hNFY α+β+γ subunits + promoter DNA

References

  1. ↑ Maity SN, de Crombrugghe B. Role of the CCAAT-binding protein CBF/NF-Y in transcription. Trends Biochem Sci. 1998 May;23(5):174-8. PMID:9612081
  2. ↑ Bargou RC, Jurchott K, Wagener C, Bergmann S, Metzner S, Bommert K, Mapara MY, Winzer KJ, Dietel M, Dorken B, Royer HD. Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Nat Med. 1997 Apr;3(4):447-50. PMID:9095180

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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