1g7q

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[[Image:1g7q.jpg|left|200px]]
[[Image:1g7q.jpg|left|200px]]
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{{Structure
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|PDB= 1g7q |SIZE=350|CAPTION= <scene name='initialview01'>1g7q</scene>, resolution 1.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1g7q", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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{{STRUCTURE_1g7q| PDB=1g7q | SCENE= }}
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|RELATEDENTRY=[[1vac|1VAC]], [[2vaa|2VAA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g7q OCA], [http://www.ebi.ac.uk/pdbsum/1g7q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1g7q RCSB]</span>
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'''CRYSTAL STRUCTURE OF MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND MUC1 VNTR PEPTIDE SAPDTRPA'''
'''CRYSTAL STRUCTURE OF MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND MUC1 VNTR PEPTIDE SAPDTRPA'''
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[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
[[Category: Yu, M.]]
[[Category: Yu, M.]]
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[[Category: h-2kb]]
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[[Category: H-2kb]]
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[[Category: mhc class i]]
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[[Category: Mhc class i]]
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[[Category: muc1]]
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[[Category: Muc1]]
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[[Category: mucin]]
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[[Category: Mucin]]
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[[Category: vntr]]
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[[Category: Vntr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:14:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:38:32 2008''
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Revision as of 14:14, 2 May 2008

Image:1g7q.jpg

Template:STRUCTURE 1g7q

CRYSTAL STRUCTURE OF MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND MUC1 VNTR PEPTIDE SAPDTRPA


Overview

Peptides bind with high affinity to MHC class I molecules by anchoring certain side-chains (anchors) into specificity pockets in the MHC peptide-binding groove. Peptides that do not contain these canonical anchor residues normally have low affinity, resulting in impaired pMHC stability and loss of immunogenicity. Here, we report the crystal structure at 1.6 A resolution of an immunogenic, low-affinity peptide from the tumor-associated antigen MUC1, bound to H-2Kb. Stable binding is still achieved despite small, non-canonical residues in the C and F anchor pockets. This structure reveals how low-affinity peptides can be utilized in the design of novel peptide-based tumor vaccines. The molecular interactions elucidated in this non-canonical low-affinity peptide MHC complex should help uncover additional immunogenic peptides from primary protein sequences and aid in the design of alternative approaches for T-cell vaccines.

About this Structure

1G7Q is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a non-canonical low-affinity peptide complexed with MHC class I: a new approach for vaccine design., Apostolopoulos V, Yu M, Corper AL, Teyton L, Pietersz GA, McKenzie IF, Wilson IA, Plebanski M, J Mol Biol. 2002 May 17;318(5):1293-305. PMID:12083518 Page seeded by OCA on Fri May 2 17:14:47 2008

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