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Insulin receptor

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<StructureSection load='3bu5' size='400' side='right' caption='Structure of human insulin receptor tyrosine kinase catalytic domain complex with insulin receptor substrate 2 peptide (green), Mg+2 ion (green) and ATP (stick model) (PDB entry [[3bu5]])' scene=''>
<StructureSection load='3bu5' size='400' side='right' caption='Structure of human insulin receptor tyrosine kinase catalytic domain complex with insulin receptor substrate 2 peptide (green), Mg+2 ion (green) and ATP (stick model) (PDB entry [[3bu5]])' scene=''>
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== Function ==
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'''Insulin receptor''' (IR) is a transmembrane receptor activated by insulin, IGF-I and IGF-II. IR is important for the regulation of glucose homeostasis and its malfunction can cause diabetics and cancer. The IR is a dimer where each monomer contains 8 distinct domains. The β-chain contains a tyrosine kinase catalytic domain (TK). For more details see [[Student Projects for UMass Chemistry 423 Spring 2012-1]].<br />
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'''Insulin receptor''' (IR) is a transmembrane receptor activated by insulin, insulin-like growth factor I and II<ref>PMID:8141246</ref>. The IR is a dimer where each monomer contains 8 distinct domains. The β-chain contains a tyrosine kinase catalytic domain (TK). For more details see [[Student Projects for UMass Chemistry 423 Spring 2012-1]].<br />
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== Disease ==
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IR is important for the regulation of glucose homeostasis and its malfunction can cause diabetics and cancer. IR is overexpressed in cancer<ref>PMID:18465356</ref>.
See also [[Insulin Receptor - kinase domain (hebrew)]].
See also [[Insulin Receptor - kinase domain (hebrew)]].
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[[2b4s]] - hIR TK domain + tyrosine-protein phosphatase<br />
[[2b4s]] - hIR TK domain + tyrosine-protein phosphatase<br />
[[1rqq]] – hIR TK domain (mutant) + adaptor protein PS
[[1rqq]] – hIR TK domain (mutant) + adaptor protein PS
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:25, 29 March 2016

Structure of human insulin receptor tyrosine kinase catalytic domain complex with insulin receptor substrate 2 peptide (green), Mg+2 ion (green) and ATP (stick model) (PDB entry 3bu5)

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