This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Bone morphogenetic protein

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(Removing all content from page)
Line 1: Line 1:
 +
<StructureSection load='2qja' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene=''>
 +
__TOC__
 +
== Function ==
 +
 +
'''Bone morphogenetic protein''' (BMP) are growth factors which can induce formation of bone and cartllage'<ref>PMID:19900831</ref>. Over 20 BMPs are known at present. BMP is part of the Transforming Growth Factor-β (TGF-β) family of proteins. For details on BMP-2 see [[Student Projects for UMass Chemistry 423 Spring 2014-4]].
 +
== Relevance ==
 +
 +
Recombinant BMP is used in oral surgery and spinal fusion.
 +
 +
== Disease ==
 +
 +
BMP-7 is involved in chronic kidney disease<ref>PMID:18508541</ref>.
 +
 +
== Structural highlights ==
 +
 +
 +
</StructureSection>
 +
==3D structures of bone morphogenetic protein==
 +
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
 +
 +
*Bone morphogenetic protein 1
 +
 +
**[[3edg]], [[3edh]] – hBMP protease domain – human<br />
 +
 +
*Bone morphogenetic protein 2
 +
 +
**[[3bmp]] – hBMP <br />
 +
**[[1reu]] – hBMP (mutant)<br />
 +
**[[4n1d]] – hBMP/Nodal <br />
 +
**[[4mid]] – hBMP/activin A <br />
 +
**[[1es7]], [[1rew]], [[2qj9]], [[2qja]], [[2qjb]] – hBMP + BMP receptor IA<br />
 +
**[[3bk3]] – hBMP + crossveinless 2<br />
 +
**[[2goo]], [[2h62]], [[2h64]] – hBMP + BMP receptor IA + activin II receptor <br />
 +
**[[4uhy]], [[4uhz]], [[4ui0]], [[4ui1]] – hBMP C terminal + repulsive guidance molecule<br />
 +
**[[4ui2]] – hBMP C terminal + repulsive guidance molecule + neogenin<br />
 +
 +
*Bone morphogenetic protein 3
 +
 +
**[[2qcq]] – hBMP <br />
 +
 +
*Bone morphogenetic protein 6
 +
 +
**[[2qcw]], [[2r52]], [[2r53]] – hBMP <br />
 +
 +
*Bone morphogenetic protein 7
 +
 +
**[[1bmp]], [[1lxi]] – hBMP <br />
 +
**[[1m4u]] – hBMP + noggin<br />
 +
**[[1lx5]] – hBMP + activin II receptor<br />
 +
 +
*Bone morphogenetic protein 9
 +
 +
**[[1zkz]], [[4mpl]] – hBMP <br />
 +
**[[4ycg]], [[4yci]] – BMP - mouse<br />
 +
 +
}}
 +
== References ==
 +
<references/>
 +
[[Category:Topic Page]]

Revision as of 12:08, 22 February 2016

Human α-defensin 1 (PDB entry 2pm4)

Drag the structure with the mouse to rotate

3D structures of bone morphogenetic protein

Updated on 22-February-2016

References

  1. ↑ Reddi AH, Reddi A. Bone morphogenetic proteins (BMPs): from morphogens to metabologens. Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):341-2. doi:, 10.1016/j.cytogfr.2009.10.015. Epub 2009 Nov 8. PMID:19900831 doi:http://dx.doi.org/10.1016/j.cytogfr.2009.10.015
  2. ↑ Mitu G, Hirschberg R. Bone morphogenetic protein-7 (BMP7) in chronic kidney disease. Front Biosci. 2008 May 1;13:4726-39. PMID:18508541

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Bone_morphogenetic_protein"
Personal tools