5e0j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5e0j is ON HOLD until Paper Publication
+
==1.20 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic (21-mer) inhibitor==
-
 
+
<StructureSection load='5e0j' size='340' side='right' caption='[[5e0j]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
-
Authors: Lovell, S., Battaile, K.P., Mehzabeen, N., Weerawarna, P.M., Kim, Y., Kankanamalage, A.C.G., Damalanka, V.C., Lushington, G.H., Alliston, K.R., Chang, K.-O., Groutas, W.C.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5e0j]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E0J FirstGlance]. <br>
-
Description: 1.20 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic (21-mer) inhibitor
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5LJ:(PHENYLMETHYL)+~{N}-[(12~{S},15~{S},18~{S})-15-(CYCLOHEXYLMETHYL)-12-(HYDROXYMETHYL)-9,14,17-TRIS(OXIDANYLIDENE)-1,8,13,16,21,22-HEXAZABICYCLO[18.2.1]TRICOSA-20(23),21-DIEN-18-YL]CARBAMATE'>5LJ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5e0g|5e0g]], [[5e0h|5e0h]]</td></tr>
-
[[Category: Battaile, K.P]]
+
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calicivirin Calicivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.66 3.4.22.66] </span></td></tr>
-
[[Category: Weerawarna, P.M]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e0j OCA], [http://pdbe.org/5e0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e0j RCSB], [http://www.ebi.ac.uk/pdbsum/5e0j PDBsum]</span></td></tr>
-
[[Category: Alliston, K.R]]
+
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/POLG_NVN68 POLG_NVN68]] Protein p48 may play a role in viral replication by interacting with host VAPA, a vesicle-associated membrane protein that plays a role in SNARE-mediated vesicle fusion. This interaction may target replication complex to intracellular membranes.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> Protein P22 may play a role in targeting replication complex to intracellular membranes.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> 3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation (By similarity).<ref>PMID:569187</ref> <ref>PMID:11160659</ref> RNA-directed RNA polymerase replicates genomic and antigenomic RNA by recognizing replications specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA encodes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).<ref>PMID:569187</ref> <ref>PMID:11160659</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Calicivirin]]
 +
[[Category: Alliston, K R]]
 +
[[Category: Battaile, K P]]
 +
[[Category: Chang, K O]]
 +
[[Category: Damalanka, V C]]
 +
[[Category: Groutas, W C]]
 +
[[Category: Kankanamalage, A C.G]]
 +
[[Category: Kim, Y]]
[[Category: Lovell, S]]
[[Category: Lovell, S]]
-
[[Category: Lushington, G.H]]
+
[[Category: Lushington, G H]]
-
[[Category: Chang, K.-O]]
+
-
[[Category: Damalanka, V.C]]
+
-
[[Category: Groutas, W.C]]
+
[[Category: Mehzabeen, N]]
[[Category: Mehzabeen, N]]
-
[[Category: Kankanamalage, A.C.G]]
+
[[Category: Weerawarna, P M]]
-
[[Category: Kim, Y]]
+
[[Category: Antiviral inhibitor]]
 +
[[Category: Cell permeable]]
 +
[[Category: Norovirus]]
 +
[[Category: Norwalk virus]]
 +
[[Category: Protease]]
 +
[[Category: Protease-protease inhibitor complex]]
 +
[[Category: Triazole macrocyclic inhibitor]]

Revision as of 19:40, 13 May 2016

1.20 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic (21-mer) inhibitor

5e0j, resolution 1.20Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5e0j"
Personal tools