5fwj

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m (Protected "5fwj" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5fwj is ON HOLD
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==Crystal structure of human JARID1C in complex with KDM5-C49==
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<StructureSection load='5fwj' size='340' side='right' caption='[[5fwj]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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Authors: SRIKANNATHASAN, V., SZYKOWSKA, A., STRAIN-DAMERELL, C., KOPEC, J., NOWAK, R., GILEADI, C., JOHANSSON, C., KUPINSKA, K., BURGESS-BROWN, N.A., Shrestha, L., Dong, W., VonDELFT, F., ARROWSMITH, C.H., BOUNTRA, C., EDWARDS, A., HUBER, K., OPPERMANN, U.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5fwj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FWJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FWJ FirstGlance]. <br>
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Description: Crystal structure of human JARID1C in complex with KDM5-C49
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MMK:2-{[(2-{[(E)-2-(DIMETHYLAMINO)ETHENYL](ETHYL)AMINO}-2-OXOETHYL)AMINO]METHYL}PYRIDINE-4-CARBOXYLIC+ACID'>MMK</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fwj OCA], [http://pdbe.org/5fwj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fwj RCSB], [http://www.ebi.ac.uk/pdbsum/5fwj PDBsum]</span></td></tr>
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[[Category: Nowak, R]]
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</table>
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[[Category: Vondelft, F]]
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== Disease ==
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[[Category: Burgess-Brown, N.A]]
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[[http://www.uniprot.org/uniprot/KDM5C_HUMAN KDM5C_HUMAN]] Syndromic X-linked intellectual disability due to JARID1C mutation. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/KDM5C_HUMAN KDM5C_HUMAN]] Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).[UniProtKB:P41230]<ref>PMID:17320160</ref> <ref>PMID:17320161</ref> <ref>PMID:17468742</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bountra, C]]
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[[Category: Burgess-Brown, N A]]
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[[Category: Dong, W]]
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[[Category: Edwards, A]]
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[[Category: Gileadi, C]]
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[[Category: Huber, K]]
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[[Category: Johansson, C]]
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[[Category: Kopec, J]]
[[Category: Kupinska, K]]
[[Category: Kupinska, K]]
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[[Category: Huber, K]]
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[[Category: Nowak, R]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Oppermann, U]]
[[Category: Shrestha, L]]
[[Category: Shrestha, L]]
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[[Category: Gileadi, C]]
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[[Category: Srikannathasan, V]]
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[[Category: Oppermann, U]]
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[[Category: Strain-Damerell, C]]
[[Category: Szykowska, A]]
[[Category: Szykowska, A]]
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[[Category: Kopec, J]]
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[[Category: VonDELFT, F]]
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[[Category: Johansson, C]]
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[[Category: Lysine-specific]]
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[[Category: Edwards, A]]
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[[Category: Lysine-specific demethylase 5c]]
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[[Category: Strain-Damerell, C]]
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[[Category: Oxidoreductase]]
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[[Category: Dong, W]]
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[[Category: Srikannathasan, V]]
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Revision as of 11:27, 12 May 2016

Crystal structure of human JARID1C in complex with KDM5-C49

5fwj, resolution 2.10Å

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